PTPRM (protein tyrosine phosphatase receptor type M)

2003-11-01  

Identity

HGNC
PTPRM
LOCATION
18p11.23
LOCUSID
5797
ALIAS
PTPRL1,R-PTP-MU,RPTPM,RPTPU,hR-PTPu
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 5797
MIM: 176888
HGNC: 9675
Ensembl: ENSG00000173482

Variants:

dbSNP: 5797
ClinVar: 5797
TCGA: ENSG00000173482
COSMIC: PTPRM

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000173482ENST00000332175P28827
ENSG00000173482ENST00000400053E7EPS8
ENSG00000173482ENST00000400060Q49AC9
ENSG00000173482ENST00000577468J3QRB4
ENSG00000173482ENST00000578916J3QLI4
ENSG00000173482ENST00000580170P28827
ENSG00000173482ENST00000583153J3KT55
ENSG00000173482ENST00000583289J3KRV2

Expression (GTEx)

0
10
20
30
40
50
60
70
80
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cell adhesion molecules (CAMs)KEGGko04514
Adherens junctionKEGGko04520
Cell adhesion molecules (CAMs)KEGGhsa04514
Adherens junctionKEGGhsa04520

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA443434Arthritis, RheumatoidDiseaseClinicalAnnotationassociatedPD24583629
PA450428methotrexateChemicalClinicalAnnotationassociatedPD24583629

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
217434922012miR-221/222 overexpession in human glioblastoma increases invasiveness by targeting the protein phosphate PTPμ.77
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
177618812007Structure of a tyrosine phosphatase adhesive interaction reveals a spacer-clamp mechanism.49
206593272010Trait-stratified genome-wide association study identifies novel and diverse genetic associations with serologic and cytokine phenotypes in systemic lupus erythematosus.47
202019262010Human variation in alcohol response is influenced by variation in neuronal signaling genes.45
196901392009Proteolytic cleavage of protein tyrosine phosphatase mu regulates glioblastoma cell migration.34
193049592009PTPmu suppresses glioma cell migration and dispersal.27
123765452002Intra- and intermolecular interactions between intracellular domains of receptor protein-tyrosine phosphatases.22
163803802006The receptor protein-tyrosine phosphatase PTPmu interacts with IQGAP1.15

Citation

Dessen P

PTPRM (protein tyrosine phosphatase receptor type M)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/41934/ptprm