PTPRO (protein tyrosine phosphatase receptor type O)

2007-02-01  

Identity

HGNC
LOCATION
12p12.3
LOCUSID
ALIAS
GLEPP1,NPHS6,PTP-OC,PTP-U2,PTPROT,PTPU2,R-PTP-O
FUSION GENES

Other Information

Locus ID:

NCBI: 5800
MIM: 600579
HGNC: 9678
Ensembl: ENSG00000151490

Variants:

dbSNP: 5800
ClinVar: 5800
TCGA: ENSG00000151490
COSMIC: PTPRO

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000151490ENST00000281171Q16827
ENSG00000151490ENST00000348962Q16827
ENSG00000151490ENST00000442921Q16827
ENSG00000151490ENST00000442921A0A024RAS9
ENSG00000151490ENST00000445537Q16827
ENSG00000151490ENST00000445537A0A024RAS9
ENSG00000151490ENST00000535311H0YH11
ENSG00000151490ENST00000535322H0YH60
ENSG00000151490ENST00000542557Q16827
ENSG00000151490ENST00000542557A0A024RAS0
ENSG00000151490ENST00000543886Q16827
ENSG00000151490ENST00000544244Q16827
ENSG00000151490ENST00000544244A0A024RAS0
ENSG00000151490ENST00000674388A0A024RAS9

Expression (GTEx)

0
5
10
15
20

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
217228582011Disruption of PTPRO causes childhood-onset nephrotic syndrome.42
153563452004Protein tyrosine phosphatase receptor-type O (PTPRO) exhibits characteristics of a candidate tumor suppressor in human lung cancer.38
168880962006Protein tyrosine phosphatase receptor-type O truncated (PTPROt) regulates SYK phosphorylation, proximal B-cell-receptor signaling, and cellular proliferation.37
198345352009Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging.27
198550812009BCL6 modulates tonic BCR signaling in diffuse large B-cell lymphomas by repressing the SYK phosphatase, PTPROt.25
175455202007Methylation and silencing of protein tyrosine phosphatase receptor type O in chronic lymphocytic leukemia.23
190957702009Estrogen-mediated suppression of the gene encoding protein tyrosine phosphatase PTPRO in human breast cancer: mechanism and role in tamoxifen sensitivity.16
221268372012Genome-wide study identifies PTPRO and WDR72 and FOXQ1-SUMO1P1 interaction associated with neurocognitive function.13

Citation

Dessen P

PTPRO (protein tyrosine phosphatase receptor type O)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45721/ptpro