PTPRS (protein tyrosine phosphatase receptor type S)

2003-12-01  

Identity

HGNC
LOCATION
19p13.3
LOCUSID
ALIAS
PTPSIGMA,R-PTP-S,R-PTP-sigma
FUSION GENES

Other Information

Locus ID:

NCBI: 5802
MIM: 601576
HGNC: 9681
Ensembl: ENSG00000105426

Variants:

dbSNP: 5802
ClinVar: 5802
TCGA: ENSG00000105426
COSMIC: PTPRS

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000105426ENST00000262963G8JL96
ENSG00000105426ENST00000586065K7ERX4
ENSG00000105426ENST00000587303Q13332
ENSG00000105426ENST00000588012Q13332
ENSG00000105426ENST00000590509Q8NHS7
ENSG00000105426ENST00000591760K7ESP0
ENSG00000105426ENST00000592099Q13332

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100

Pathways

PathwaySourceExternal ID
Neuronal SystemREACTOMER-HSA-112316
Extracellular matrix organizationREACTOMER-HSA-1474244
ECM proteoglycansREACTOMER-HSA-3000178
SALM protein interactions at the synapsesREACTOMER-HSA-8849932
Protein-protein interactions at synapsesREACTOMER-HSA-6794362

References

Pubmed IDYearTitleCitations
214547542011Proteoglycan-specific molecular switch for RPTPσ clustering and neuronal extension.117
201394222010Trans-synaptic adhesions between netrin-G ligand-3 (NGL-3) and receptor tyrosine phosphatases LAR, protein-tyrosine phosphatase delta (PTPdelta), and PTPsigma via specific domains regulate excitatory synapse formation.65
220657492011Genomic dissection of the epidermal growth factor receptor (EGFR)/PI3K pathway reveals frequent deletion of the EGFR phosphatase PTPRS in head and neck cancers.34
253855462014Structural basis for extracellular cis and trans RPTPσ signal competition in synaptogenesis.32
176142802007Protein-tyrosine phosphatase sigma is associated with ulcerative colitis.24
213039302011Identification of PTPsigma as an autophagic phosphatase.24
123765452002Intra- and intermolecular interactions between intracellular domains of receptor protein-tyrosine phosphatases.22
262311202015Protein Tyrosine Phosphatase PTPRS Is an Inhibitory Receptor on Human and Murine Plasmacytoid Dendritic Cells.13
259952222015Targeting phosphatase-dependent proteoglycan switch for rheumatoid arthritis therapy.12
190003052008Frameshift mutations in coding repeats of protein tyrosine phosphatase genes in colorectal tumors with microsatellite instability.10

Citation

Dessen P

PTPRS (protein tyrosine phosphatase receptor type S)

Atlas Genet Cytogenet Oncol Haematol. 2003-12-01

Online version: http://atlasgeneticsoncology.org/gene/41938/ptprs