PTRH2 (peptidyl-tRNA hydrolase 2)

2009-09-01  

Identity

HGNC
LOCATION
17q23.1
LOCUSID
ALIAS
BIT1,CFAP37,CGI-147,IMNEPD,PTH,PTH
FUSION GENES

Other Information

Locus ID:

NCBI: 51651
MIM: 608625
HGNC: 24265
Ensembl: ENSG00000141378

Variants:

dbSNP: 51651
ClinVar: 51651
TCGA: ENSG00000141378
COSMIC: PTRH2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000141378ENST00000393038Q9Y3E5
ENSG00000141378ENST00000409433J3KQ48
ENSG00000141378ENST00000470557Q9Y3E5

Expression (GTEx)

0
5
10
15
20

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
DeubiquitinationREACTOMER-HSA-5688426
Ub-specific processing proteasesREACTOMER-HSA-5689880

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
150063562004A mitochondrial protein, Bit1, mediates apoptosis regulated by integrins and Groucho/TLE corepressors.54
232481182013Application of a proapoptotic peptide to intratumorally spreading cancer therapy.18
187035092008Protein kinase D is a positive regulator of Bit1 apoptotic function.17
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.17
229520442012TLE1 is an anoikis regulator and is downregulated by Bit1 in breast cancer cells.16
175116792007Induction of Anoikis following myoblast transplantation into SCID mouse muscles requires the Bit1 and FADD pathways.15
213830072011Bit-1 mediates integrin-dependent cell survival through activation of the NFkappaB pathway.13
218868292011Metastasis of tumor cells is enhanced by downregulation of Bit1.11
250031982014The anoikis effector Bit1 displays tumor suppressive function in lung cancer cells.9
269567282016Bit1 knockdown contributes to growth suppression as well as the decreases of migration and invasion abilities in esophageal squamous cell carcinoma via suppressing FAK-paxillin pathway.7

Citation

Dessen P

PTRH2 (peptidyl-tRNA hydrolase 2)

Atlas Genet Cytogenet Oncol Haematol. 2009-09-01

Online version: http://atlasgeneticsoncology.org/gene/51070/ptrh2