PTX3 (pentraxin 3)

2003-11-01  

Identity

HGNC
PTX3
LOCATION
3q25.32
LOCUSID
5806
ALIAS
TNFAIP5,TSG-14

Other Information

Locus ID:

NCBI: 5806
MIM: 602492
HGNC: 9692
Ensembl: ENSG00000163661

Variants:

dbSNP: 5806
ClinVar: 5806
TCGA: ENSG00000163661
COSMIC: PTX3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000163661ENST00000295927P26022

Expression (GTEx)

0
500
1000
1500
2000
2500
3000
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
256797622015PTX3 is an extrinsic oncosuppressor regulating complement-dependent inflammation in cancer.99
244764322014Genetic PTX3 deficiency and aspergillosis in stem-cell transplantation.87
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
126459452003Biochemical and functional characterization of the interaction between pentraxin 3 and C1q.78
182925652008Antiviral activity of the long chain pentraxin PTX3 against influenza viruses.73
120064112002Production of the long pentraxin PTX3 in advanced atherosclerotic plaques.70
176115892007DC-SIGN (CD209), pentraxin 3 and vitamin D receptor gene variants associate with pulmonary tuberculosis risk in West Africans.70
176115892007DC-SIGN (CD209), pentraxin 3 and vitamin D receptor gene variants associate with pulmonary tuberculosis risk in West Africans.70
190502612008Binding of the long pentraxin PTX3 to factor H: interacting domains and function in the regulation of complement activation.62
196329902009Synergy between ficolin-2 and pentraxin 3 boosts innate immune recognition and complement deposition.62

Citation

Dessen P

PTX3 (pentraxin 3)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/41948/ptx3