Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 5813
MIM: 600473
HGNC: 9701
Ensembl: ENSG00000185129
Variants:
dbSNP: 5813
ClinVar: 5813
TCGA: ENSG00000185129
COSMIC: PURA
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000185129 | ENST00000331327 | Q00577 |
| ENSG00000185129 | ENST00000502351 | A0A494C0X8 |
| ENSG00000185129 | ENST00000505703 | A0A494C0H6 |
| ENSG00000185129 | ENST00000651386 | Q00577 |
Expression (GTEx)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA447197 | Attention Deficit Disorder with Hyperactivity | Disease | ClinicalAnnotation | associated | PD | 29382897 | |
| PA450464 | methylphenidate | Chemical | ClinicalAnnotation | associated | PD | 29382897 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38655849 | 2024 | PURA syndrome-causing mutations impair PUR-domain integrity and affect P-body association. | 2 |
| 38777099 | 2024 | PURA and GLUT1: Sweet partners for brain health. | 0 |
| 39000020 | 2024 | Purine-Rich Element Binding Protein Alpha, a Nuclear Matrix Protein, Has a Role in Prostate Cancer Progression. | 0 |
| 38655849 | 2024 | PURA syndrome-causing mutations impair PUR-domain integrity and affect P-body association. | 2 |
| 38777099 | 2024 | PURA and GLUT1: Sweet partners for brain health. | 0 |
| 39000020 | 2024 | Purine-Rich Element Binding Protein Alpha, a Nuclear Matrix Protein, Has a Role in Prostate Cancer Progression. | 0 |
| 36651277 | 2023 | Depletion of the RNA-binding protein PURA triggers changes in posttranscriptional gene regulation and loss of P-bodies. | 2 |
| 37149929 | 2023 | Genome-wide CRISPR/Cas9 screening identifies a targetable MEST-PURA interaction in cancer metastasis. | 3 |
| 37909329 | 2023 | DUSP8 induces TGF-β-stimulated IL-9 transcription and Th9-mediated allergic inflammation by promoting nuclear export of Pur-α. | 2 |
| 36651277 | 2023 | Depletion of the RNA-binding protein PURA triggers changes in posttranscriptional gene regulation and loss of P-bodies. | 2 |
| 37149929 | 2023 | Genome-wide CRISPR/Cas9 screening identifies a targetable MEST-PURA interaction in cancer metastasis. | 3 |
| 37909329 | 2023 | DUSP8 induces TGF-β-stimulated IL-9 transcription and Th9-mediated allergic inflammation by promoting nuclear export of Pur-α. | 2 |
| 35945453 | 2022 | Forming cytoplasmic stress granules PURα suppresses mRNA translation initiation of IGFBP3 to promote esophageal squamous cell carcinoma progression. | 4 |
| 35945453 | 2022 | Forming cytoplasmic stress granules PURα suppresses mRNA translation initiation of IGFBP3 to promote esophageal squamous cell carcinoma progression. | 4 |
| 33142842 | 2020 | PURα Promotes the Transcriptional Activation of PCK2 in Oesophageal Squamous Cell Carcinoma Cells. | 6 |
Citation
Dessen P
PURA (purine rich element binding protein A)
Atlas Genet Cytogenet Oncol Haematol. 2003-02-01
Online version: http://atlasgeneticsoncology.org/gene/41951/pura
