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PXDNL (peroxidasin like)

Identity

Alias (NCBI)PMR1
PRM1
VPO2
HGNC (Hugo) PXDNL
HGNC Alias symbFLJ25471
PMR1
HGNC Alias namepolysomal ribonuclease 1 homolog (Xenopus)
HGNC Previous nameperoxidasin homolog-like (Drosophila)
 peroxidasin homolog (Drosophila)-like
LocusID (NCBI) 137902
Atlas_Id 72419
Location 8q11.22  [Link to chromosome band 8q11]
Location_base_pair Starts at 51319577 and ends at 51809445 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
FAM168A (11q13.4) / PXDNL (8q11.22)FOXP1 (3p13) / PXDNL (8q11.22)PXDNL (8q11.22) / USP8 (15q21.2)
FOXP1 PXDNLFAM168A PXDNL

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 3 ]
  t(3;8)(p13;q11) FOXP1/PXDNL
t(8;11)(q11;q13) FAM168A/PXDNL
t(8;15)(q11;q21) PXDNL/USP8


External links

Nomenclature
HGNC (Hugo)PXDNL   26359
Cards
Entrez_Gene (NCBI)PXDNL    peroxidasin like
AliasesPMR1; PRM1; VPO2
GeneCards (Weizmann)PXDNL
Ensembl hg19 (Hinxton)ENSG00000147485 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000147485 [Gene_View]  ENSG00000147485 [Sequence]  chr8:51319577-51809445 [Contig_View]  PXDNL [Vega]
ICGC DataPortalENSG00000147485
TCGA cBioPortalPXDNL
AceView (NCBI)PXDNL
Genatlas (Paris)PXDNL
SOURCE (Princeton)PXDNL
Genetics Home Reference (NIH)PXDNL
Genomic and cartography
GoldenPath hg38 (UCSC)PXDNL  -     chr8:51319577-51809445 -  8q11.22   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PXDNL  -     8q11.22   [Description]    (hg19-Feb_2009)
GoldenPathPXDNL - 8q11.22 [CytoView hg19]  PXDNL - 8q11.22 [CytoView hg38]
ImmunoBaseENSG00000147485
genome Data Viewer NCBIPXDNL [Mapview hg19]  
OMIM615904   
Gene and transcription
Genbank (Entrez)AI127081 AK058200 AK131524 AY877349 BC132813
RefSeq transcript (Entrez)NM_144651
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PXDNL
Alternative Splicing GalleryENSG00000147485
Gene ExpressionPXDNL [ NCBI-GEO ]   PXDNL [ EBI - ARRAY_EXPRESS ]   PXDNL [ SEEK ]   PXDNL [ MEM ]
Gene Expression Viewer (FireBrowse)PXDNL [ Firebrowse - Broad ]
GenevisibleExpression of PXDNL in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)137902
GTEX Portal (Tissue expression)PXDNL
Human Protein AtlasENSG00000147485-PXDNL [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtA1KZ92   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtA1KZ92  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProA1KZ92
Splice isoforms : SwissVarA1KZ92
Catalytic activity : Enzyme1.11.1.7 [ Enzyme-Expasy ]   1.11.1.71.11.1.7 [ IntEnz-EBI ]   1.11.1.7 [ BRENDA ]   1.11.1.7 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusA1KZ92
Domaine pattern : Prosite (Expaxy)IG_LIKE (PS50835)    LRR (PS51450)    PEROXIDASE_3 (PS50292)    VWFC_1 (PS01208)    VWFC_2 (PS50184)   
Domains : Interpro (EBI)Cys-rich_flank_reg_C    Haem_peroxidase_animal    Haem_peroxidase_sf    Haem_peroxidase_sf_animal    Ig-like_dom    Ig-like_dom_sf    Ig-like_fold    Ig_I-set    Ig_sub    Ig_sub2    Leu-rich_rpt    Leu-rich_rpt_typical-subtyp    LRR_dom_sf    Peroxidasin_peroxidase    PXDNL    VWF_dom   
Domain families : Pfam (Sanger)An_peroxidase (PF03098)    I-set (PF07679)    LRR_8 (PF13855)    VWC (PF00093)   
Domain families : Pfam (NCBI)pfam03098    pfam07679    pfam13855    pfam00093   
Domain families : Smart (EMBL)IG (SM00409)  IGc2 (SM00408)  LRR_TYP (SM00369)  LRRCT (SM00082)  VWC (SM00214)  
Conserved Domain (NCBI)PXDNL
Blocks (Seattle)PXDNL
SuperfamilyA1KZ92
Human Protein Atlas [tissue]ENSG00000147485-PXDNL [tissue]
Peptide AtlasA1KZ92
HPRD08693
IPIIPI00065049   IPI00890814   IPI00981534   
Protein Interaction databases
DIP (DOE-UCLA)A1KZ92
IntAct (EBI)A1KZ92
BioGRIDPXDNL
STRING (EMBL)PXDNL
ZODIACPXDNL
Ontologies - Pathways
QuickGOA1KZ92
Ontology : AmiGOendonuclease activity  peroxidase activity  peroxidase activity  extracellular space  extracellular space  cytoplasm  response to oxidative stress  heme binding  hydrogen peroxide catabolic process  metal ion binding  oxidation-reduction process  nucleic acid phosphodiester bond hydrolysis  cellular oxidant detoxification  
Ontology : EGO-EBIendonuclease activity  peroxidase activity  peroxidase activity  extracellular space  extracellular space  cytoplasm  response to oxidative stress  heme binding  hydrogen peroxide catabolic process  metal ion binding  oxidation-reduction process  nucleic acid phosphodiester bond hydrolysis  cellular oxidant detoxification  
NDEx NetworkPXDNL
Atlas of Cancer Signalling NetworkPXDNL
Wikipedia pathwaysPXDNL
Orthology - Evolution
OrthoDB137902
GeneTree (enSembl)ENSG00000147485
Phylogenetic Trees/Animal Genes : TreeFamPXDNL
HOGENOMA1KZ92
Homologs : HomoloGenePXDNL
Homology/Alignments : Family Browser (UCSC)PXDNL
Gene fusions - Rearrangements
Fusion PortalFOXP1 PXDNL
Fusion PortalFAM168A PXDNL
Fusion : QuiverPXDNL
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPXDNL [hg38]
dbVarPXDNL
ClinVarPXDNL
MonarchPXDNL
1000_GenomesPXDNL 
Exome Variant ServerPXDNL
GNOMAD BrowserENSG00000147485
Varsome BrowserPXDNL
Genomic Variants (DGV)PXDNL [DGVbeta]
DECIPHERPXDNL [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPXDNL 
Mutations
ICGC Data PortalPXDNL 
TCGA Data PortalPXDNL 
Broad Tumor PortalPXDNL
OASIS PortalPXDNL [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPXDNL  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPXDNL
Mutations and Diseases : HGMDPXDNL
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PXDNL
DgiDB (Drug Gene Interaction Database)PXDNL
DoCM (Curated mutations)PXDNL (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PXDNL (select a term)
intoGenPXDNL
Cancer3DPXDNL(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM615904   
Orphanet
DisGeNETPXDNL
MedgenPXDNL
Genetic Testing Registry PXDNL
NextProtA1KZ92 [Medical]
GENETestsPXDNL
Target ValidationPXDNL
Huge Navigator PXDNL [HugePedia]
ClinGenPXDNL
Clinical trials, drugs, therapy
MyCancerGenomePXDNL
Protein Interactions : CTD
Pharm GKB GenePA142671110
Clinical trialPXDNL
Miscellaneous
canSAR (ICR)PXDNL (select the gene name)
HarmonizomePXDNL
DataMed IndexPXDNL
Probes
Litterature
PubMed19 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePXDNL
EVEXPXDNL
GoPubMedPXDNL
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sat Dec 5 17:24:02 CET 2020

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