PYGB (glycogen phosphorylase B)

2007-05-01  

Identity

HGNC
LOCATION
20p11.21
LOCUSID
ALIAS
GPBB
FUSION GENES

Other Information

Locus ID:

NCBI: 5834
MIM: 138550
HGNC: 9723
Ensembl: ENSG00000100994

Variants:

dbSNP: 5834
ClinVar: 5834
TCGA: ENSG00000100994
COSMIC: PYGB

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000100994ENST00000216962P11216
ENSG00000100994ENST00000428458H0Y4Z6

Expression (GTEx)

0
50
100
150
200
250
300
350
400
450

Pathways

PathwaySourceExternal ID
Starch and sucrose metabolismKEGGko00500
Insulin signaling pathwayKEGGko04910
Starch and sucrose metabolismKEGGhsa00500
Insulin signaling pathwayKEGGhsa04910
Metabolic pathwaysKEGGhsa01100
Glucagon signaling pathwayKEGGhsa04922
Glucagon signaling pathwayKEGGko04922
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
MetabolismREACTOMER-HSA-1430728
Metabolism of carbohydratesREACTOMER-HSA-71387
Glucose metabolismREACTOMER-HSA-70326
Glycogen breakdown (glycogenolysis)REACTOMER-HSA-70221
Insulin resistanceKEGGhsa04931
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
384836042024Unveiling the role of PYGB in pancreatic cancer: a novel diagnostic biomarker and gene therapy target.0
384836042024Unveiling the role of PYGB in pancreatic cancer: a novel diagnostic biomarker and gene therapy target.0
316788282020Using SERS-based microfluidic paper-based device (μPAD) for calibration-free quantitative measurement of AMI cardiac biomarkers.13
321918392020PYGB facilitates cell proliferation and invasiveness in non-small cell lung cancer by activating the Wnt-β-catenin signaling pathway.9
324629862020PYGB Promoted Tumor Progression by Regulating Wnt/β-Catenin Pathway in Gastric Cancer.10
316788282020Using SERS-based microfluidic paper-based device (μPAD) for calibration-free quantitative measurement of AMI cardiac biomarkers.13
321918392020PYGB facilitates cell proliferation and invasiveness in non-small cell lung cancer by activating the Wnt-β-catenin signaling pathway.9
324629862020PYGB Promoted Tumor Progression by Regulating Wnt/β-Catenin Pathway in Gastric Cancer.10
315364952019Breast cancers utilize hypoxic glycogen stores via PYGB, the brain isoform of glycogen phosphorylase, to promote metastatic phenotypes.21
316270922019Glycogen phosphorylase B promotes ovarian cancer progression via Wnt/β-catenin signaling and is regulated by miR-133a-3p.36
315364952019Breast cancers utilize hypoxic glycogen stores via PYGB, the brain isoform of glycogen phosphorylase, to promote metastatic phenotypes.21
316270922019Glycogen phosphorylase B promotes ovarian cancer progression via Wnt/β-catenin signaling and is regulated by miR-133a-3p.36
290304202018New biomarker for acute ischaemic stroke: plasma glycogen phosphorylase isoenzyme BB.11
298452652018PYGB siRNA inhibits the cell proliferation of human osteosarcoma cell lines.5
301061102018Silencing of PYGB suppresses growth and promotes the apoptosis of prostate cancer cells via the NF‑κB/Nrf2 signaling pathway.19

Citation

Dessen P

PYGB (glycogen phosphorylase B)

Atlas Genet Cytogenet Oncol Haematol. 2007-05-01

Online version: http://atlasgeneticsoncology.org/gene/47533/pygb