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QARS1 (glutaminyl-tRNA synthetase 1)

Identity

Other aliasGLNRS
MSCCA
PRO2195
QARS
HGNC (Hugo) QARS1
LocusID (NCBI) 5859
Atlas_Id 72437
Location 3p21.31  [Link to chromosome band 3p21]
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute


External links

Nomenclature
HGNC (Hugo)QARS1   9751
Cards
Entrez_Gene (NCBI)QARS1  5859  glutaminyl-tRNA synthetase 1
AliasesGLNRS; MSCCA; PRO2195; QARS
GeneCards (Weizmann)QARS1
Ensembl hg19 (Hinxton)ENSG00000172053 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000172053 [Gene_View]  ENSG00000172053 [Sequence]  - [Contig_View]  QARS1 [Vega]
ICGC DataPortalENSG00000172053
TCGA cBioPortalQARS1
AceView (NCBI)QARS1
Genatlas (Paris)QARS1
WikiGenes5859
SOURCE (Princeton)QARS1
Genetics Home Reference (NIH)QARS1
Genomic and cartography
GoldenPath hg38 (UCSC)QARS1  -  
GoldenPath hg19 (UCSC)QARS1  -  
GoldenPathQARS1 - [CytoView hg19]  QARS1 - [CytoView hg38]
ImmunoBaseENSG00000172053
Mapping of homologs : NCBIQARS1 [Mapview hg19]  QARS1 [Mapview hg38]
OMIM603727   615760   
Gene and transcription
Genbank (Entrez)AF130067 AK056815 AK222510 AK290523 AK293260
RefSeq transcript (Entrez)NM_001272073 NM_005051
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)QARS1
Alternative Splicing GalleryENSG00000172053
Gene ExpressionQARS1 [ NCBI-GEO ]   QARS1 [ EBI - ARRAY_EXPRESS ]   QARS1 [ SEEK ]   QARS1 [ MEM ]
Gene Expression Viewer (FireBrowse)QARS1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5859
GTEX Portal (Tissue expression)QARS1
Human Protein AtlasENSG00000172053-QARS1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP47897   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP47897  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP47897
Splice isoforms : SwissVarP47897
PhosPhoSitePlusP47897
Domaine pattern : Prosite (Expaxy)AA_TRNA_LIGASE_I (PS00178)   
Domains : Interpro (EBI)aa-tRNA-synth_I_CS    Gln-tRNA-synth    Gln-tRNA-synth_Ib_RNA-bd_2    Gln-tRNA-synth_Ib_RNA-bd_N    Gln-tRNA-synth_Ib_RNA-bd_N_1    Gln-tRNA-synth_Ib_RNA-bd_N_2    Glu/Gln-tRNA-synth    Glu/Gln-tRNA-synth_Ib_cat-dom    Glu/Gln-tRNA-synth_Ib_codon-bd    Rbsml_L25/Gln-tRNA_synth_N    Ribosomal_L25/Gln-tRNA_synth    Rossmann-like_a/b/a_fold   
Domain families : Pfam (Sanger)tRNA-synt_1c (PF00749)    tRNA-synt_1c_C (PF03950)    tRNA_synt_1c_R1 (PF04558)    tRNA_synt_1c_R2 (PF04557)   
Domain families : Pfam (NCBI)pfam00749    pfam03950    pfam04558    pfam04557   
Conserved Domain (NCBI)QARS1
DMDM Disease mutations5859
Blocks (Seattle)QARS1
PDB (RSDB)4R3Z    4YE6    4YE8    4YE9   
PDB Europe4R3Z    4YE6    4YE8    4YE9   
PDB (PDBSum)4R3Z    4YE6    4YE8    4YE9   
PDB (IMB)4R3Z    4YE6    4YE8    4YE9   
Structural Biology KnowledgeBase4R3Z    4YE6    4YE8    4YE9   
SCOP (Structural Classification of Proteins)4R3Z    4YE6    4YE8    4YE9   
CATH (Classification of proteins structures)4R3Z    4YE6    4YE8    4YE9   
SuperfamilyP47897
Human Protein Atlas [tissue]ENSG00000172053-QARS1 [tissue]
Peptide AtlasP47897
HPRD07223
IPIIPI00925046   IPI00910548   IPI00792753   IPI00925735   IPI00925511   IPI00925203   IPI00925012   IPI00924591   
Protein Interaction databases
DIP (DOE-UCLA)P47897
IntAct (EBI)P47897
FunCoupENSG00000172053
BioGRIDQARS1
STRING (EMBL)QARS1
ZODIACQARS1
Ontologies - Pathways
QuickGOP47897
Ontology : AmiGOglutamine-tRNA ligase activity  glutamine-tRNA ligase activity  glutamine-tRNA ligase activity  protein kinase inhibitor activity  protein binding  ATP binding  cytoplasm  mitochondrial matrix  cytosol  cytosol  cytosol  tRNA aminoacylation for protein translation  glutaminyl-tRNA aminoacylation  glutaminyl-tRNA aminoacylation  negative regulation of protein kinase activity  brain development  aminoacyl-tRNA synthetase multienzyme complex  aminoacyl-tRNA synthetase multienzyme complex  protein kinase binding  negative regulation of stress-activated MAPK cascade  protein-containing complex  negative regulation of transcription, DNA-templated  negative regulation of apoptotic signaling pathway  
Ontology : EGO-EBIglutamine-tRNA ligase activity  glutamine-tRNA ligase activity  glutamine-tRNA ligase activity  protein kinase inhibitor activity  protein binding  ATP binding  cytoplasm  mitochondrial matrix  cytosol  cytosol  cytosol  tRNA aminoacylation for protein translation  glutaminyl-tRNA aminoacylation  glutaminyl-tRNA aminoacylation  negative regulation of protein kinase activity  brain development  aminoacyl-tRNA synthetase multienzyme complex  aminoacyl-tRNA synthetase multienzyme complex  protein kinase binding  negative regulation of stress-activated MAPK cascade  protein-containing complex  negative regulation of transcription, DNA-templated  negative regulation of apoptotic signaling pathway  
Pathways : KEGGAminoacyl-tRNA biosynthesis    Glutamate metabolism   
NDEx NetworkQARS1
Atlas of Cancer Signalling NetworkQARS1
Wikipedia pathwaysQARS1
Orthology - Evolution
OrthoDB5859
GeneTree (enSembl)ENSG00000172053
Phylogenetic Trees/Animal Genes : TreeFamQARS1
HOGENOMP47897
Homologs : HomoloGeneQARS1
Homology/Alignments : Family Browser (UCSC)QARS1
Gene fusions - Rearrangements
Fusion : QuiverQARS1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerQARS1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)QARS1
dbVarQARS1
ClinVarQARS1
1000_GenomesQARS1 
Exome Variant ServerQARS1
ExAC (Exome Aggregation Consortium)ENSG00000172053
GNOMAD BrowserENSG00000172053
Varsome BrowserQARS1
Genetic variants : HAPMAP5859
Genomic Variants (DGV)QARS1 [DGVbeta]
DECIPHERQARS1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisQARS1 
Mutations
ICGC Data PortalQARS1 
TCGA Data PortalQARS1 
Broad Tumor PortalQARS1
OASIS PortalQARS1 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDQARS1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch QARS1
DgiDB (Drug Gene Interaction Database)QARS1
DoCM (Curated mutations)QARS1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)QARS1 (select a term)
intoGenQARS1
Cancer3DQARS1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603727    615760   
Orphanet22918   
DisGeNETQARS1
MedgenQARS1
Genetic Testing Registry QARS1
NextProtP47897 [Medical]
TSGene5859
GENETestsQARS1
Target ValidationQARS1
Huge Navigator QARS1 [HugePedia]
snp3D : Map Gene to Disease5859
BioCentury BCIQQARS1
ClinGenQARS1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5859
Chemical/Pharm GKB GenePA34093
Clinical trialQARS1
Miscellaneous
canSAR (ICR)QARS1 (select the gene name)
HarmonizomeQARS1
DataMed IndexQARS1
Probes
Litterature
PubMed96 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineQARS1
EVEXQARS1
GoPubMedQARS1
iHOPQARS1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Mar 11 19:42:53 CET 2020

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