QPRT (quinolinate phosphoribosyltransferase)

2014-11-01  

Identity

HGNC
LOCATION
16p11.2
LOCUSID
ALIAS
HEL-S-90n,QPRTase

Other Information

Locus ID:

NCBI: 23475
MIM: 606248
HGNC: 9755
Ensembl: ENSG00000103485

Variants:

dbSNP: 23475
ClinVar: 23475
TCGA: ENSG00000103485
COSMIC: QPRT

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000103485ENST00000395384Q15274
ENSG00000103485ENST00000449759Q15274
ENSG00000103485ENST00000449759C9JCJ5
ENSG00000103485ENST00000562473H3BP73

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Nicotinate and nicotinamide metabolismKEGGko00760
Nicotinate and nicotinamide metabolismKEGGhsa00760
Metabolic pathwaysKEGGhsa01100
MetabolismREACTOMER-HSA-1430728
Metabolism of vitamins and cofactorsREACTOMER-HSA-196854
Metabolism of water-soluble vitamins and cofactorsREACTOMER-HSA-196849
Nicotinate metabolismREACTOMER-HSA-196807

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
193210142009QPRT: a potential marker for follicular thyroid carcinoma including minimal invasive variant; a gene expression, RNA and immunohistochemical study.8
278896112017Anti-apoptotic quinolinate phosphoribosyltransferase (QPRT) is a target gene of Wilms' tumor gene 1 (WT1) protein in leukemic cells.7
240386712014The crystal structure of human quinolinic acid phosphoribosyltransferase in complex with its inhibitor phthalic acid.6
268055892016Structural Insights into the Quaternary Catalytic Mechanism of Hexameric Human Quinolinate Phosphoribosyltransferase, a Key Enzyme in de novo NAD Biosynthesis.5
304433112018Loss of the Chr16p11.2 ASD candidate gene QPRT leads to aberrant neuronal differentiation in the SH-SY5Y neuronal cell model.4
287249152017Quinolinate Phosphoribosyltransferase is an Antiviral Host Factor Against Hepatitis C Virus Infection.2

Citation

Dessen P

QPRT (quinolinate phosphoribosyltransferase)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/72441/qprt