QRFP (pyroglutamylated RFamide peptide)

2013-05-01  

Identity

HGNC
LOCATION
9q34.12
LOCUSID
ALIAS
26RFa,P518

Other Information

Locus ID:

NCBI: 347148
MIM: 609795
HGNC: 29982
Ensembl: ENSG00000188710

Variants:

dbSNP: 347148
ClinVar: 347148
TCGA: ENSG00000188710
COSMIC: QRFP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000188710ENST00000343079P83859
ENSG00000188710ENST00000623824P83859

Expression (GTEx)

0
1
2
3

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Peptide ligand-binding receptorsREACTOMER-HSA-375276
Orexin and neuropeptides FF and QRFP bind to their respective receptorsREACTOMER-HSA-389397
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (q) signalling eventsREACTOMER-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
127145922003Identification and characterization of a novel RF-amide peptide ligand for orphan G-protein-coupled receptor SP9155.42
205346932010GPR103b functions in the peripheral regulation of adipogenesis.10
158089082005Structural studies on 26RFa, a novel human RFamide-related peptide with orexigenic activity.0
158910092005Identification of 26RFa from frog brain: a novel hypothalamic neuropeptide with orexigenic activity in mammals.0
168990662006Anatomical distribution and biochemical characterization of the novel RFamide peptide 26RFa in the human hypothalamus and spinal cord.0
224663352012Orexigenic neuropeptide 26RFa: new evidence for an adaptive profile of appetite regulation in anorexia nervosa.0
228631472013The neuropeptide 26RFa is expressed in human prostate cancer and stimulates the neuroendocrine differentiation and the migration of androgeno-independent prostate cancer cells.0
258585632015Hypothalamic Neuropeptide 26RFa Acts as an Incretin to Regulate Glucose Homeostasis.0

Citation

Dessen P

QRFP (pyroglutamylated RFamide peptide)

Atlas Genet Cytogenet Oncol Haematol. 2013-05-01

Online version: http://atlasgeneticsoncology.org/gene/53324/qrfp