QSOX1 (quiescin sulfhydryl oxidase 1)

2010-02-01  

Identity

HGNC
LOCATION
1q25.2
LOCUSID
ALIAS
Q6,QSCN6
FUSION GENES

Other Information

Locus ID:

NCBI: 5768
MIM: 603120
HGNC: 9756
Ensembl: ENSG00000116260

Variants:

dbSNP: 5768
ClinVar: 5768
TCGA: ENSG00000116260
COSMIC: QSOX1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000116260ENST00000367600O00391
ENSG00000116260ENST00000367600A0A140VKE5
ENSG00000116260ENST00000367602O00391
ENSG00000116260ENST00000392029A8MXT8
ENSG00000116260ENST00000443059H0Y5Z8

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
HemostasisREACTOMER-HSA-109582
Platelet activation, signaling and aggregationREACTOMER-HSA-76002
Response to elevated platelet cytosolic Ca2+REACTOMER-HSA-76005
Platelet degranulationREACTOMER-HSA-114608
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
237043712013A secreted disulfide catalyst controls extracellular matrix composition and function.48
183934492008Human quiescin-sulfhydryl oxidase, QSOX1: probing internal redox steps by mutagenesis.40
228015042012The dynamic disulphide relay of quiescin sulphydryl oxidase.36
173310722007Intracellular catalysis of disulfide bond formation by the human sulfhydryl oxidase, QSOX1.35
197959082009Analysis of the plasma peptidome from pancreas cancer patients connects a peptide in plasma to overexpression of the parent protein in tumors.29
219891042011Quiescin sulfhydryl oxidase 1 promotes invasion of pancreatic tumor cells mediated by matrix metalloproteinases.20
235369622013Expression of quiescin sulfhydryl oxidase 1 is associated with a highly invasive phenotype and correlates with a poor prognosis in Luminal B breast cancer.19
202116212010QSOX contains a pseudo-dimer of functional and degenerate sulfhydryl oxidase domains.18
240088272013HIF1 contributes to hypoxia-induced pancreatic cancer cells invasion via promoting QSOX1 expression.17
234608392013Elevated transcription of the gene QSOX1 encoding quiescin Q6 sulfhydryl oxidase 1 in breast cancer.13

Citation

Dessen P

QSOX1 (quiescin sulfhydryl oxidase 1)

Atlas Genet Cytogenet Oncol Haematol. 2010-02-01

Online version: http://atlasgeneticsoncology.org/gene/51357/qsox1