RAB13 (RAB13, member RAS oncogene family)

2003-11-01  

Identity

HGNC
RAB13
LOCATION
1q21.3
LOCUSID
5872
ALIAS
GIG4
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 5872
MIM: 602672
HGNC: 9762
Ensembl: ENSG00000143545

Variants:

dbSNP: 5872
ClinVar: 5872
TCGA: ENSG00000143545
COSMIC: RAB13

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000143545ENST00000368575P51153
ENSG00000143545ENST00000614713A0A087WWB9

Expression (GTEx)

0
50
100
150
200
250
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Tight junctionKEGGko04530
Tight junctionKEGGhsa04530
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Translocation of GLUT4 to the plasma membraneREACTOMER-HSA-1445148
RAB GEFs exchange GTP for GDP on RABsREACTOMER-HSA-8876198
RAB geranylgeranylationREACTOMER-HSA-8873719

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
155281892005Rab13 mediates the continuous endocytic recycling of occludin to the cell surface.74
264717302015Phosphoproteomic screening identifies Rab GTPases as novel downstream targets of PINK1.62
187793672008Rab13 regulates membrane trafficking between TGN and recycling endosomes in polarized epithelial cells.48
257134152015DENND2B activates Rab13 at the leading edge of migrating cells and promotes metastatic behavior.29
178911732008Involvement of Rab13 and JRAB/MICAL-L2 in epithelial cell scattering.17
198856262009Dislocation of Rab13 and vasodilator-stimulated phosphoprotein in inactive colon epithelium in patients with Crohn's disease.11
270447462016Regulation of Cancer Cell Behavior by the Small GTPase Rab13.10
225625572012Rab13 is upregulated during osteoclast differentiation and associates with small vesicles revealing polarized distribution in resorbing cells.8
269691622016Rab13 Traffics on Vesicles Independent of Prenylation.5
280873442017Up-regulation of the active form of small GTPase Rab13 promotes macroautophagy in vascular endothelial cells.5

Citation

Dessen P

RAB13 (RAB13, member RAS oncogene family)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/41958/rab13