RAB18 (RAB18, member RAS oncogene family)

2003-12-01  

Identity

HGNC
RAB18
LOCATION
10p12.1
LOCUSID
22931
ALIAS
RAB18LI1,WARBM3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 22931
MIM: 602207
HGNC: 14244
Ensembl: ENSG00000099246

Variants:

dbSNP: 22931
ClinVar: 22931
TCGA: ENSG00000099246
COSMIC: RAB18

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000099246ENST00000356940Q9NP72
ENSG00000099246ENST00000375802Q5W0J0
ENSG00000099246ENST00000423465H0Y6T8
ENSG00000099246ENST00000535776Q9NP72
ENSG00000099246ENST00000611151A0A087X163
ENSG00000099246ENST00000621805Q9NP72

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Intra-Golgi and retrograde Golgi-to-ER trafficREACTOMER-HSA-6811442
Golgi-to-ER retrograde transportREACTOMER-HSA-8856688
COPI-independent Golgi-to-ER retrograde trafficREACTOMER-HSA-6811436
Neutrophil degranulationREACTOMER-HSA-6798695
RAB GEFs exchange GTP for GDP on RABsREACTOMER-HSA-8876198
RAB geranylgeranylationREACTOMER-HSA-8873719

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
159145362005Rab18 localizes to lipid droplets and induces their close apposition to the endoplasmic reticulum-derived membrane.125
162077212005Regulated localization of Rab18 to lipid droplets: effects of lipolytic stimulation and inhibition of lipid droplet catabolism.106
186644962008Rab18 and Rab43 have key roles in ER-Golgi trafficking.56
239354972013Rab18 binds to hepatitis C virus NS5A and promotes interaction between sites of viral replication and lipid droplets.53
214739852011Loss-of-function mutations in RAB18 cause Warburg micro syndrome.51
234718812013Hepatitis B virus X protein upregulates oncogene Rab18 to result in the dysregulation of lipogenesis and proliferation of hepatoma cells.37
248916042014Rab18 and a Rab18 GEF complex are required for normal ER structure.36
246964712014Rab18 facilitates dengue virus infection by targeting fatty acid synthase to sites of viral replication.34
234205202013Mutation spectrum in RAB3GAP1, RAB3GAP2, and RAB18 and genotype-phenotype correlations in warburg micro syndrome and Martsolf syndrome.31
168089052006Recruitment of TIP47 to lipid droplets is controlled by the putative hydrophobic cleft.22

Citation

Dessen P

RAB18 (RAB18, member RAS oncogene family)

Atlas Genet Cytogenet Oncol Haematol. 2003-12-01

Online version: http://atlasgeneticsoncology.org/gene/41961/rab18