RAB1A (RAB1A, member RAS oncogene family)

2003-02-01  

Identity

HGNC
LOCATION
2p14
LOCUSID
ALIAS
RAB1,YPT1
FUSION GENES

Other Information

Locus ID:

NCBI: 5861
MIM: 179508
HGNC: 9758
Ensembl: ENSG00000138069

Variants:

dbSNP: 5861
ClinVar: 5861
TCGA: ENSG00000138069
COSMIC: RAB1A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000138069ENST00000398529P62820
ENSG00000138069ENST00000409751E7END7
ENSG00000138069ENST00000409784P62820
ENSG00000138069ENST00000409784Q5U0I6
ENSG00000138069ENST00000409892P62820
ENSG00000138069ENST00000649427P62820
ENSG00000138069ENST00000649427Q5U0I6

Expression (GTEx)

0
50
100
150
200
250
300

Pathways

PathwaySourceExternal ID
LegionellosisKEGGko05134
LegionellosisKEGGhsa05134
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Asparagine N-linked glycosylationREACTOMER-HSA-446203
Transport to the Golgi and subsequent modificationREACTOMER-HSA-948021
ER to Golgi Anterograde TransportREACTOMER-HSA-199977
COPII (Coat Protein 2) Mediated Vesicle TransportREACTOMER-HSA-204005
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
M PhaseREACTOMER-HSA-68886
Mitotic ProphaseREACTOMER-HSA-68875
Golgi Cisternae Pericentriolar Stack ReorganizationREACTOMER-HSA-162658
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
COPI-mediated anterograde transportREACTOMER-HSA-6807878
Intra-Golgi and retrograde Golgi-to-ER trafficREACTOMER-HSA-6811442
Golgi-to-ER retrograde transportREACTOMER-HSA-8856688
COPI-dependent Golgi-to-ER retrograde trafficREACTOMER-HSA-6811434
RAB GEFs exchange GTP for GDP on RABsREACTOMER-HSA-8876198
RAB geranylgeranylationREACTOMER-HSA-8873719

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
273346152016The C9orf72 protein interacts with Rab1a and the ULK1 complex to regulate initiation of autophagy.112
176840572007Analysis of GTPase-activating proteins: Rab1 and Rab43 are key Rabs required to maintain a functional Golgi complex in human cells.92
254469002014Rab1A is an mTORC1 activator and a colorectal oncogene.85
209808132011Antibacterial autophagy occurs at PI(3)P-enriched domains of the endoplasmic reticulum and requires Rab1 GTPase.52
179010502007TBC1D20 is a Rab1 GTPase-activating protein that mediates hepatitis C virus replication.51
237708512014MiR-221 promotes the development of androgen independence in prostate cancer cells via downregulation of HECTD2 and RAB1A.48
237166962013Ypt1 recruits the Atg1 kinase to the preautophagosomal structure.45
201769512010Structural mechanism of host Rab1 activation by the bifunctional Legionella type IV effector SidM/DrrA.38
206395772010Regulation of Integrin β 1 recycling to lipid rafts by Rab1a to promote cell migration.37
181673582008Coordination of golgin tethering and SNARE assembly: GM130 binds syntaxin 5 in a p115-regulated manner.36

Citation

Dessen P

RAB1A (RAB1A, member RAS oncogene family)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41962/rab1a