RAB25 (RAB25, member RAS oncogene family)

2004-02-01  

Identity

HGNC
LOCATION
1q22
LOCUSID
ALIAS
CATX-8,RAB11C

Other Information

Locus ID:

NCBI: 57111
MIM: 612942
HGNC: 18238
Ensembl: ENSG00000132698

Variants:

dbSNP: 57111
ClinVar: 57111
TCGA: ENSG00000132698
COSMIC: RAB25

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000132698ENST00000361084P57735

Expression (GTEx)

0
50
100
150
200
250
300
350
400
450

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
RAB geranylgeranylationREACTOMER-HSA-8873719

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
179252262007Rab25 associates with alpha5beta1 integrin to promote invasive migration in 3D microenvironments.159
201976232010Loss of Rab25 promotes the development of intestinal neoplasia in mice and is associated with human colorectal adenocarcinomas.58
197954432010Tumor suppressor function of Rab25 in triple-negative breast cancer.41
229913052012Rab25 is a tumor suppressor gene with antiangiogenic and anti-invasive activities in esophageal squamous cell carcinoma.36
222531972012Rab25 increases cellular ATP and glycogen stores protecting cancer cells from bioenergetic stress.29
233403002013Rab25 regulates invasion and metastasis in head and neck cancer.29
237226512013Overexpression of Rab25 contributes to metastasis of bladder cancer through induction of epithelial-mesenchymal transition and activation of Akt/GSK-3β/Snail signaling.24
173939862006Knockdown of RAB25 expression by RNAi inhibits growth of human epithelial ovarian cancer cells in vitro and in vivo.23
231764892012Rab25 in cancer: a brief update.21
226446762012Increased expression of Rab25 in breast cancer correlates with lymphatic metastasis.18

Citation

Dessen P

RAB25 (RAB25, member RAS oncogene family)

Atlas Genet Cytogenet Oncol Haematol. 2004-02-01

Online version: http://atlasgeneticsoncology.org/gene/41970/rab25