Atlas of Genetics and Cytogenetics in Oncology and Haematology

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RAB27A (RAB27A, member RAS oncogene family)

Identity

Alias_symbol (synonym)RAB27
RAM
GS2
HsT18676
Other alias
HGNC (Hugo) RAB27A
LocusID (NCBI) 5873
Atlas_Id 41972
Location 15q21.3  [Link to chromosome band 15q21]
Location_base_pair Starts at 55202966 and ends at 55270909 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CCDC159 (19p13.2) / RAB27A (15q21.3)MAP2K5 (15q23) / RAB27A (15q21.3)RAB27A (15q21.3) / NEDD4 (15q21.3)
RAB27A (15q21.3) / RAB27A (15q21.3)RAB27A (15q21.3) / SMPDL3A (6q22.31)RAB27A (15q21.3) / SQRDL (15q21.1)
RSL24D1 (15q21.3) / RAB27A (15q21.3)SCGB1A1 (11q12.3) / RAB27A (15q21.3)MAP2K5 15q23 / RAB27A 15q21.3
RAB27A 15q21.3 / NEDD4 15q21.3RAB27A 15q21.3 / SQRDL 15q21.1RSL24D1 15q21.3 / RAB27A 15q21.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 3 ]
  RAB27A/NEDD4 (15q21)
RSL24D1/RAB27A (15q21)
t(15;15)(q21;q23) MAP2K5/RAB27A

External links

Nomenclature
HGNC (Hugo)RAB27A   9766
LRG (Locus Reference Genomic)LRG_96
Cards
Entrez_Gene (NCBI)RAB27A  5873  RAB27A, member RAS oncogene family
AliasesGS2; HsT18676; RAB27; RAM
GeneCards (Weizmann)RAB27A
Ensembl hg19 (Hinxton)ENSG00000069974 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000069974 [Gene_View]  ENSG00000069974 [Sequence]  chr15:55202966-55270909 [Contig_View]  RAB27A [Vega]
ICGC DataPortalENSG00000069974
TCGA cBioPortalRAB27A
AceView (NCBI)RAB27A
Genatlas (Paris)RAB27A
WikiGenes5873
SOURCE (Princeton)RAB27A
Genetics Home Reference (NIH)RAB27A
Genomic and cartography
GoldenPath hg38 (UCSC)RAB27A  -     chr15:55202966-55270909 -  15q21.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RAB27A  -     15q21.3   [Description]    (hg19-Feb_2009)
GoldenPathRAB27A - 15q21.3 [CytoView hg19]  RAB27A - 15q21.3 [CytoView hg38]
ImmunoBaseENSG00000069974
Mapping of homologs : NCBIRAB27A [Mapview hg19]  RAB27A [Mapview hg38]
OMIM603868   607624   
Gene and transcription
Genbank (Entrez)AF125393 AF498953 AK312836 AV661679 BC107680
RefSeq transcript (Entrez)NM_004580 NM_183234 NM_183235 NM_183236
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)RAB27A
Cluster EST : UnigeneHs.735555 [ NCBI ]
CGAP (NCI)Hs.735555
Alternative Splicing GalleryENSG00000069974
Gene ExpressionRAB27A [ NCBI-GEO ]   RAB27A [ EBI - ARRAY_EXPRESS ]   RAB27A [ SEEK ]   RAB27A [ MEM ]
Gene Expression Viewer (FireBrowse)RAB27A [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5873
GTEX Portal (Tissue expression)RAB27A
Human Protein AtlasENSG00000069974-RAB27A [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP51159   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP51159  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP51159
Splice isoforms : SwissVarP51159
PhosPhoSitePlusP51159
Domaine pattern : Prosite (Expaxy)RAB (PS51419)   
Domains : Interpro (EBI)P-loop_NTPase    Small_GTP-bd_dom    Small_GTPase   
Domain families : Pfam (Sanger)Ras (PF00071)   
Domain families : Pfam (NCBI)pfam00071   
Conserved Domain (NCBI)RAB27A
DMDM Disease mutations5873
Blocks (Seattle)RAB27A
SuperfamilyP51159
Human Protein Atlas [tissue]ENSG00000069974-RAB27A [tissue]
Peptide AtlasP51159
HPRD04845
IPIIPI00016381   IPI00219858   
Protein Interaction databases
DIP (DOE-UCLA)P51159
IntAct (EBI)P51159
FunCoupENSG00000069974
BioGRIDRAB27A
STRING (EMBL)RAB27A
ZODIACRAB27A
Ontologies - Pathways
QuickGOP51159
Ontology : AmiGOphotoreceptor outer segment  GTPase activity  GTPase activity  protein binding  GTP binding  GTP binding  extracellular region  lysosome  late endosome  Golgi apparatus  cytosol  protein targeting  intracellular protein transport  exocytosis  blood coagulation  positive regulation of gene expression  apical plasma membrane  GDP binding  antigen processing and presentation  protein domain specific binding  secretory granule  melanocyte differentiation  dendrite  secretory granule membrane  myosin V binding  melanosome localization  melanosome transport  melanosome transport  Rab protein signal transduction  multivesicular body membrane  Weibel-Palade body  melanosome membrane  specific granule lumen  multivesicular body organization  melanosome  melanosome  neutrophil degranulation  cytotoxic T cell degranulation  natural killer cell degranulation  positive regulation of exocytosis  positive regulation of exocytosis  synaptic vesicle transport  positive regulation of phagocytosis  extracellular exosome  exocytic vesicle  multivesicular body sorting pathway  complement-dependent cytotoxicity  positive regulation of regulated secretory pathway  positive regulation of regulated secretory pathway  positive regulation of reactive oxygen species biosynthetic process  positive regulation of constitutive secretory pathway  exosomal secretion  
Ontology : EGO-EBIphotoreceptor outer segment  GTPase activity  GTPase activity  protein binding  GTP binding  GTP binding  extracellular region  lysosome  late endosome  Golgi apparatus  cytosol  protein targeting  intracellular protein transport  exocytosis  blood coagulation  positive regulation of gene expression  apical plasma membrane  GDP binding  antigen processing and presentation  protein domain specific binding  secretory granule  melanocyte differentiation  dendrite  secretory granule membrane  myosin V binding  melanosome localization  melanosome transport  melanosome transport  Rab protein signal transduction  multivesicular body membrane  Weibel-Palade body  melanosome membrane  specific granule lumen  multivesicular body organization  melanosome  melanosome  neutrophil degranulation  cytotoxic T cell degranulation  natural killer cell degranulation  positive regulation of exocytosis  positive regulation of exocytosis  synaptic vesicle transport  positive regulation of phagocytosis  extracellular exosome  exocytic vesicle  multivesicular body sorting pathway  complement-dependent cytotoxicity  positive regulation of regulated secretory pathway  positive regulation of regulated secretory pathway  positive regulation of reactive oxygen species biosynthetic process  positive regulation of constitutive secretory pathway  exosomal secretion  
NDEx NetworkRAB27A
Atlas of Cancer Signalling NetworkRAB27A
Wikipedia pathwaysRAB27A
Orthology - Evolution
OrthoDB5873
GeneTree (enSembl)ENSG00000069974
Phylogenetic Trees/Animal Genes : TreeFamRAB27A
HOGENOMP51159
Homologs : HomoloGeneRAB27A
Homology/Alignments : Family Browser (UCSC)RAB27A
Gene fusions - Rearrangements
Fusion : MitelmanMAP2K5/RAB27A [15q23/15q21.3]  [t(15;15)(q21;q23)]  
Fusion : MitelmanRAB27A/NEDD4 [15q21.3/15q21.3]  [t(15;15)(q21;q21)]  
Fusion : MitelmanRAB27A/SQRDL [15q21.3/15q21.1]  [t(15;15)(q21;q21)]  
Fusion : MitelmanRSL24D1/RAB27A [15q21.3/15q21.3]  [t(15;15)(q21;q21)]  
Fusion PortalMAP2K5 15q23 RAB27A 15q21.3 HNSC
Fusion PortalRAB27A 15q21.3 NEDD4 15q21.3 BRCA
Fusion PortalRAB27A 15q21.3 SQRDL 15q21.1 BRCA
Fusion PortalRSL24D1 15q21.3 RAB27A 15q21.3 LUAD
Fusion : QuiverRAB27A
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRAB27A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RAB27A
dbVarRAB27A
ClinVarRAB27A
1000_GenomesRAB27A 
Exome Variant ServerRAB27A
ExAC (Exome Aggregation Consortium)ENSG00000069974
GNOMAD BrowserENSG00000069974
Varsome BrowserRAB27A
Genetic variants : HAPMAP5873
Genomic Variants (DGV)RAB27A [DGVbeta]
DECIPHERRAB27A [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRAB27A 
Mutations
ICGC Data PortalRAB27A 
TCGA Data PortalRAB27A 
Broad Tumor PortalRAB27A
OASIS PortalRAB27A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRAB27A  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DRAB27A
Mutations and Diseases : HGMDRAB27A
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)**PUBLIC** CCHMC Molecular Genetics Laboratory Mutation Database
BioMutasearch RAB27A
DgiDB (Drug Gene Interaction Database)RAB27A
DoCM (Curated mutations)RAB27A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RAB27A (select a term)
intoGenRAB27A
Cancer3DRAB27A(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603868    607624   
Orphanet11503   
DisGeNETRAB27A
MedgenRAB27A
Genetic Testing Registry RAB27A
NextProtP51159 [Medical]
TSGene5873
GENETestsRAB27A
Target ValidationRAB27A
Huge Navigator RAB27A [HugePedia]
snp3D : Map Gene to Disease5873
BioCentury BCIQRAB27A
ClinGenRAB27A
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5873
Chemical/Pharm GKB GenePA34117
Clinical trialRAB27A
Miscellaneous
canSAR (ICR)RAB27A (select the gene name)
DataMed IndexRAB27A
Probes
Litterature
PubMed141 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRAB27A
EVEXRAB27A
GoPubMedRAB27A
iHOPRAB27A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Nov 13 18:03:40 CET 2019
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