RAB27B (RAB27B, member RAS oncogene family)

2003-11-01  

Identity

HGNC
LOCATION
18q21.2
LOCUSID
ALIAS
C25KG
FUSION GENES

Other Information

Locus ID:

NCBI: 5874
MIM: 603869
HGNC: 9767
Ensembl: ENSG00000041353

Variants:

dbSNP: 5874
ClinVar: 5874
TCGA: ENSG00000041353
COSMIC: RAB27B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000041353ENST00000262094O00194
ENSG00000041353ENST00000586570K7ES41
ENSG00000041353ENST00000592334K7EJ38

Expression (GTEx)

0
5
10
15
20

Pathways

PathwaySourceExternal ID
Pancreatic secretionKEGGko04972
Pancreatic secretionKEGGhsa04972
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
HemostasisREACTOMER-HSA-109582
Platelet activation, signaling and aggregationREACTOMER-HSA-76002
Response to elevated platelet cytosolic Ca2+REACTOMER-HSA-76005
Platelet degranulationREACTOMER-HSA-114608
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
RAB GEFs exchange GTP for GDP on RABsREACTOMER-HSA-8876198
RAB geranylgeranylationREACTOMER-HSA-8873719

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
252612342014Cellular disposal of miR23b by RAB27-dependent exosome release is linked to acquisition of metastatic properties.91
204841052010Effect of the secretory small GTPase Rab27B on breast cancer growth, invasion, and metastasis.82
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
121221172002Functional redundancy of Rab27 proteins and the pathogenesis of Griscelli syndrome.52
233900682013Vacuolar H+ ATPase expression and activity is required for Rab27B-dependent invasive growth and metastasis of breast cancer.28
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
269137202016MiR-193a-3p and miR-193a-5p suppress the metastasis of human osteosarcoma cells by down-regulating Rab27B and SRR, respectively.23
213041802010The secretory small GTPase Rab27B as a marker for breast cancer progression.21
263483972015Rab7a and Rab27b control secretion of endothelial microRNA through extracellular vesicles.21
236658962013Rab27 GTPases distribute extracellular nanomaps for invasive growth and metastasis: implications for prognosis and treatment.18

Citation

Dessen P

RAB27B (RAB27B, member RAS oncogene family)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/41973/rab27b