RAB37 (RAB37, member RAS oncogene family)

2003-12-01  

Identity

HGNC
LOCATION
17q25.1
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 326624
MIM: 609956
HGNC: 30268
Ensembl: ENSG00000172794

Variants:

dbSNP: 326624
ClinVar: 326624
TCGA: ENSG00000172794
COSMIC: RAB37

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000172794ENST00000340415A8MSP2
ENSG00000172794ENST00000392610A8MTC6
ENSG00000172794ENST00000392612Q96AX2
ENSG00000172794ENST00000392613Q96AX2
ENSG00000172794ENST00000392613A0A024R8K6
ENSG00000172794ENST00000392614Q96AX2
ENSG00000172794ENST00000392615A8MZI4
ENSG00000172794ENST00000402449Q96AX2
ENSG00000172794ENST00000481224Q96AX2
ENSG00000172794ENST00000481224A0A024R8K6
ENSG00000172794ENST00000528438B7Z3L0
ENSG00000172794ENST00000613645Q96AX2
ENSG00000172794ENST00000613645A0A024R8K6

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Neutrophil degranulationREACTOMER-HSA-6798695
RAB geranylgeranylationREACTOMER-HSA-8873719

References

Pubmed IDYearTitleCitations
329266502020Methionine represses the autophagy of gastric cancer stem cells via promoting the methylation and phosphorylation of RAB37.5
329266502020Methionine represses the autophagy of gastric cancer stem cells via promoting the methylation and phosphorylation of RAB37.5
292299962018RAB37 interacts directly with ATG5 and promotes autophagosome formation via regulating ATG5-12-16 complex assembly.41
297174872018Rab37 in lung cancer mediates exocytosis of soluble ST2 and thus skews macrophages toward tumor-suppressing phenotype.14
301313852018RAB37 Hypermethylation Regulates Metastasis and Resistance to Docetaxel-Based Induction Chemotherapy in Nasopharyngeal Carcinoma.17
301585792018Rab37 mediates exocytosis of secreted frizzled-related protein 1 to inhibit Wnt signaling and thus suppress lung cancer stemness.18
301651962018VAMP8, a vesicle-SNARE required for RAB37-mediated exocytosis, possesses a tumor metastasis suppressor function.16
292299962018RAB37 interacts directly with ATG5 and promotes autophagosome formation via regulating ATG5-12-16 complex assembly.41
297174872018Rab37 in lung cancer mediates exocytosis of soluble ST2 and thus skews macrophages toward tumor-suppressing phenotype.14
301313852018RAB37 Hypermethylation Regulates Metastasis and Resistance to Docetaxel-Based Induction Chemotherapy in Nasopharyngeal Carcinoma.17
301585792018Rab37 mediates exocytosis of secreted frizzled-related protein 1 to inhibit Wnt signaling and thus suppress lung cancer stemness.18
301651962018VAMP8, a vesicle-SNARE required for RAB37-mediated exocytosis, possesses a tumor metastasis suppressor function.16
281517212017Dysregulation of Rab37-Mediated Cross-talk between Cancer Cells and Endothelial Cells via Thrombospondin-1 Promotes Tumor Neovasculature and Metastasis.30
281517212017Dysregulation of Rab37-Mediated Cross-talk between Cancer Cells and Endothelial Cells via Thrombospondin-1 Promotes Tumor Neovasculature and Metastasis.30
251835452014Small GTPase Rab37 targets tissue inhibitor of metalloproteinase 1 for exocytosis and thus suppresses tumour metastasis.33

Citation

Dessen P

RAB37 (RAB37, member RAS oncogene family)

Atlas Genet Cytogenet Oncol Haematol. 2003-12-01

Online version: http://atlasgeneticsoncology.org/gene/41985/rab37