RAB37 (RAB37, member RAS oncogene family)

2003-12-01 Affiliation

Identity

HGNC

RAB37

LOCATION

17q25.1

LOCUSID

326624

ALIAS

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 326624
MIM: 609956
HGNC: 30268
Ensembl: ENSG00000172794

Variants:

dbSNP: 326624
ClinVar: 326624
TCGA: ENSG00000172794
COSMIC: RAB37

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000172794	ENST00000340415	A8MSP2
ENSG00000172794	ENST00000392610	A8MTC6
ENSG00000172794	ENST00000392612	Q96AX2
ENSG00000172794	ENST00000392613	Q96AX2
ENSG00000172794	ENST00000392613	A0A024R8K6
ENSG00000172794	ENST00000392614	Q96AX2
ENSG00000172794	ENST00000392615	A8MZI4
ENSG00000172794	ENST00000402449	Q96AX2
ENSG00000172794	ENST00000481224	Q96AX2
ENSG00000172794	ENST00000481224	A0A024R8K6
ENSG00000172794	ENST00000528438	B7Z3L0
ENSG00000172794	ENST00000613645	Q96AX2
ENSG00000172794	ENST00000613645	A0A024R8K6

Expression (GTEx)

100

150

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Metabolism of proteins	REACTOME	R-HSA-392499
Post-translational protein modification	REACTOME	R-HSA-597592
Immune System	REACTOME	R-HSA-168256
Innate Immune System	REACTOME	R-HSA-168249
Neutrophil degranulation	REACTOME	R-HSA-6798695
RAB geranylgeranylation	REACTOME	R-HSA-8873719

References

Pubmed ID	Year	Title	Citations
28151721	2017	Dysregulation of Rab37-Mediated Cross-talk between Cancer Cells and Endothelial Cells via Thrombospondin-1 Promotes Tumor Neovasculature and Metastasis.	17
19148500	2009	Involvement of TMEM22 overexpression in the growth of renal cell carcinoma cells.	16
25183545	2014	Small GTPase Rab37 targets tissue inhibitor of metalloproteinase 1 for exocytosis and thus suppresses tumour metastasis.	15
29229996	2018	RAB37 interacts directly with ATG5 and promotes autophagosome formation via regulating ATG5-12-16 complex assembly.	9
30165196	2018	VAMP8, a vesicle-SNARE required for RAB37-mediated exocytosis, possesses a tumor metastasis suppressor function.	3
29717487	2018	Rab37 in lung cancer mediates exocytosis of soluble ST2 and thus skews macrophages toward tumor-suppressing phenotype.	2
30158579	2018	Rab37 mediates exocytosis of secreted frizzled-related protein 1 to inhibit Wnt signaling and thus suppress lung cancer stemness.	1
18687502	2009	Frequent down-regulation of hRAB37 in metastatic tumor by genetic and epigenetic mechanisms in lung cancer.	0
23372429	2013	An association study on genetic polymorphisms of Rab37 gene with the risk of esophageal squamous cell carcinoma in a Chinese Han population.	0
23826383	2013	The GTPase Rab37 Participates in the Control of Insulin Exocytosis.	0

Citation

Dessen P

RAB37 (RAB37, member RAS oncogene family)

Atlas Genet Cytogenet Oncol Haematol. 2003-12-01

Online version: http://atlasgeneticsoncology.org/gene/41985/rab37