RAB3A (RAB3A, member RAS oncogene family)

2003-02-01 Affiliation

Identity

HGNC

RAB3A

LOCATION

19p13.11

LOCUSID

5864

ALIAS

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 5864
MIM: 179490
HGNC: 9777
Ensembl: ENSG00000105649

Variants:

dbSNP: 5864
ClinVar: 5864
TCGA: ENSG00000105649
COSMIC: RAB3A

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000105649	ENST00000222256	P20336
ENSG00000105649	ENST00000222256	A0A024R7I7
ENSG00000105649	ENST00000464076	S4R3Q3
ENSG00000105649	ENST00000481914	M0R257

Expression (GTEx)

100

200

300

400

500

600

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Synaptic vesicle cycle	KEGG	ko04721
Synaptic vesicle cycle	KEGG	hsa04721
Insulin secretion	KEGG	hsa04911
Metabolism of proteins	REACTOME	R-HSA-392499
Post-translational protein modification	REACTOME	R-HSA-597592
Neuronal System	REACTOME	R-HSA-112316
Transmission across Chemical Synapses	REACTOME	R-HSA-112315
Neurotransmitter Release Cycle	REACTOME	R-HSA-112310
Norepinephrine Neurotransmitter Release Cycle	REACTOME	R-HSA-181430
Serotonin Neurotransmitter Release Cycle	REACTOME	R-HSA-181429
Glutamate Neurotransmitter Release Cycle	REACTOME	R-HSA-210500
Dopamine Neurotransmitter Release Cycle	REACTOME	R-HSA-212676
Acetylcholine Neurotransmitter Release Cycle	REACTOME	R-HSA-264642
GABA synthesis, release, reuptake and degradation	REACTOME	R-HSA-888590
Immune System	REACTOME	R-HSA-168256
Innate Immune System	REACTOME	R-HSA-168249
Vesicle-mediated transport	REACTOME	R-HSA-5653656
Membrane Trafficking	REACTOME	R-HSA-199991
Neutrophil degranulation	REACTOME	R-HSA-6798695
RAB GEFs exchange GTP for GDP on RABs	REACTOME	R-HSA-8876198
RAB geranylgeranylation	REACTOME	R-HSA-8873719

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
19923287	2009	APP anterograde transport requires Rab3A GTPase activity for assembly of the transport vesicle.	45
19546222	2009	Epac activates the small G proteins Rap1 and Rab3A to achieve exocytosis.	38
23344955	2013	α-Synuclein membrane association is regulated by the Rab3a recycling machinery and presynaptic activity.	35
18559336	2008	Rab3GEP is the non-redundant guanine nucleotide exchange factor for Rab27a in melanocytes.	23
22753498	2012	Rab27 and Rab3 sequentially regulate human sperm dense-core granule exocytosis.	23
17625073	2007	Membrane-permeant Rab3A triggers acrosomal exocytosis in living human sperm.	19
16099449	2005	Cholesterol content regulates acrosomal exocytosis by enhancing Rab3A plasma membrane association.	12
21349835	2011	Myosin5a tail associates directly with Rab3A-containing compartments in neurons.	11
12937130	2003	Glomerular podocytes possess the synaptic vesicle molecule Rab3A and its specific effector rabphilin-3a.	9
24965146	2014	Rab3a promotes brain tumor initiation and progression.	9

Citation

Dessen P

RAB3A (RAB3A, member RAS oncogene family)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41989/rab3a