RAB3D (RAB3D, member RAS oncogene family)

2003-02-01  

Identity

HGNC
LOCATION
19p13.2
LOCUSID
ALIAS
D2-2,GOV,RAB16,RAD3D
FUSION GENES

Other Information

Locus ID:

NCBI: 9545
MIM: 604350
HGNC: 9779
Ensembl: ENSG00000105514

Variants:

dbSNP: 9545
ClinVar: 9545
TCGA: ENSG00000105514
COSMIC: RAB3D

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000105514ENST00000222120O95716
ENSG00000105514ENST00000222120A0A024R7G2
ENSG00000105514ENST00000589655O95716
ENSG00000105514ENST00000589655A0A024R7G2

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45

Pathways

PathwaySourceExternal ID
Pancreatic secretionKEGGko04972
Pancreatic secretionKEGGhsa04972
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Neutrophil degranulationREACTOMER-HSA-6798695
RAB geranylgeranylationREACTOMER-HSA-8873719

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
200385312010RAB26 and RAB3D are direct transcriptional targets of MIST1 that regulate exocrine granule maturation.46
152572872004Rab3D and annexin A2 play a role in regulated secretion of vWF, but not tPA, from endothelial cells.42
258236632015High expression of small GTPase Rab3D promotes cancer progression and metastasis.24
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.17
217020092011Changes in Rab3D expression and distribution in the acini of Sjögren's syndrome patients are associated with loss of cell polarity and secretory dysfunction.12
270460942016High expression of Rab3D predicts poor prognosis and associates with tumor progression in colorectal cancer.11
284727552017Silencing of Rab3D suppresses the proliferation and invasion of esophageal squamous cell carcinoma cells.8
235269412013Rab3D is critical for secretory granule maturation in PC12 cells.5

Citation

Dessen P

RAB3D (RAB3D, member RAS oncogene family)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41992/rab3d