RAB43 (RAB43, member RAS oncogene family)

2004-02-01 Affiliation

Identity

HGNC

RAB43

LOCATION

3q21.3

LOCUSID

339122

ALIAS

RAB11B,RAB41

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 339122
HGNC: 19983
Ensembl: ENSG00000172780

Variants:

dbSNP: 339122
ClinVar: 339122
TCGA: ENSG00000172780
COSMIC: RAB43

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000172780	ENST00000315150	Q86YS6
ENSG00000172780	ENST00000393304	Q86YS6
ENSG00000172780	ENST00000393305	Q86YS6
ENSG00000172780	ENST00000393307	Q86YS6
ENSG00000172780	ENST00000393308	Q86YS6
ENSG00000172780	ENST00000457077	C9JFM7
ENSG00000172780	ENST00000476465	Q86YS6
ENSG00000172780	ENST00000615093	Q86YS6

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Metabolism of proteins	REACTOME	R-HSA-392499
Post-translational protein modification	REACTOME	R-HSA-597592
Vesicle-mediated transport	REACTOME	R-HSA-5653656
Membrane Trafficking	REACTOME	R-HSA-199991
Intra-Golgi and retrograde Golgi-to-ER traffic	REACTOME	R-HSA-6811442
Retrograde transport at the Trans-Golgi-Network	REACTOME	R-HSA-6811440
RAB geranylgeranylation	REACTOME	R-HSA-8873719

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
17684057	2007	Analysis of GTPase-activating proteins: Rab1 and Rab43 are key Rabs required to maintain a functional Golgi complex in human cells.	92
17562788	2007	Specific Rab GTPase-activating proteins define the Shiga toxin and epidermal growth factor uptake pathways.	71
18664496	2008	Rab18 and Rab43 have key roles in ER-Golgi trafficking.	56
23615442	2013	Toxoplasma gondii salvages sphingolipids from the host Golgi through the rerouting of selected Rab vesicles to the parasitophorous vacuole.	32
24248336	2013	Structural basis of myosin V Rab GTPase-dependent cargo recognition.	31
21680502	2011	Analysis of Rab GTPase-activating proteins indicates that Rab1a/b and Rab43 are important for herpes simplex virus 1 secondary envelopment.	30
23589291	2013	The serum- and glucocorticoid-inducible kinases SGK1 and SGK3 regulate hERG channel expression via ubiquitin ligase Nedd4-2 and GTPase Rab11.	19
29233918	2017	RhoB controls the Rab11-mediated recycling and surface reappearance of LFA-1 in migrating T lymphocytes.	5
15018353	2003	Isolation, expression pattern of a novel human RAB gene RAB41 and characterization of its intronless homolog RAB41P.	0
28075478	2017	High expression of RAB43 predicts poor prognosis and is associated with epithelial-mesenchymal transition in gliomas.	0

Citation

Dessen P

RAB43 (RAB43, member RAS oncogene family)

Atlas Genet Cytogenet Oncol Haematol. 2004-02-01

Online version: http://atlasgeneticsoncology.org/gene/41997/rab43