RAB5A (RAB5A, member RAS oncogene family)

2003-08-01  

Identity

HGNC
LOCATION
3p24.3
LOCUSID
ALIAS
RAB5
FUSION GENES

Other Information

Locus ID:

NCBI: 5868
MIM: 179512
HGNC: 9783
Ensembl: ENSG00000144566

Variants:

dbSNP: 5868
ClinVar: 5868
TCGA: ENSG00000144566
COSMIC: RAB5A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000144566ENST00000273047P20339
ENSG00000144566ENST00000273047A0A024R2K1
ENSG00000144566ENST00000412966F8WCY6
ENSG00000144566ENST00000422242P20339
ENSG00000144566ENST00000443878C9J3X8
ENSG00000144566ENST00000446547F8WD79

Expression (GTEx)

0
10
20
30
40
50
60
70

Pathways

PathwaySourceExternal ID
Amyotrophic lateral sclerosis (ALS)KEGGko05014
Amyotrophic lateral sclerosis (ALS)KEGGhsa05014
EndocytosisKEGGko04144
EndocytosisKEGGhsa04144
Vasopressin-regulated water reabsorptionKEGGko04962
Vasopressin-regulated water reabsorptionKEGGhsa04962
PhagosomeKEGGko04145
PhagosomeKEGGhsa04145
AmoebiasisKEGGko05146
AmoebiasisKEGGhsa05146
TuberculosisKEGGko05152
TuberculosisKEGGhsa05152
Ras signaling pathwayKEGGhsa04014
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
HemostasisREACTOMER-HSA-109582
Factors involved in megakaryocyte development and platelet productionREACTOMER-HSA-983231
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Phospholipid metabolismREACTOMER-HSA-1483257
PI MetabolismREACTOMER-HSA-1483255
Synthesis of PIPs at the plasma membraneREACTOMER-HSA-1660499
Clathrin-mediated endocytosisREACTOMER-HSA-8856828
RAB GEFs exchange GTP for GDP on RABsREACTOMER-HSA-8876198
TBC/RABGAPsREACTOMER-HSA-8854214
RAB geranylgeranylationREACTOMER-HSA-8873719

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
150163782004APPL proteins link Rab5 to nuclear signal transduction via an endosomal compartment.202
180057332007Coxsackievirus entry across epithelial tight junctions requires occludin and the small GTPases Rab34 and Rab5.107
127612232003Rab5-stimulated up-regulation of the endocytic pathway increases intracellular beta-cleaved amyloid precursor protein carboxyl-terminal fragment levels and Abeta production.93
153285302004The Rab5 effector Rabankyrin-5 regulates and coordinates different endocytic mechanisms.90
173011522007Rab 5 is required for the cellular entry of dengue and West Nile viruses.88
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
171730372007Dynein is required for receptor sorting and the morphogenesis of early endosomes.80
187255402008SopB promotes phosphatidylinositol 3-phosphate formation on Salmonella vacuoles by recruiting Rab5 and Vps34.74
218357922011Rab5 and class III phosphoinositide 3-kinase Vps34 are involved in hepatitis C virus NS4B-induced autophagy.72
204576102010Regulation of mTORC1 by the Rab and Arf GTPases.64

Citation

Dessen P

RAB5A (RAB5A, member RAS oncogene family)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/42001/rab5a