RAB6A (RAB6A, member RAS oncogene family)

2003-11-01  

Identity

HGNC
LOCATION
11q13.4
LOCUSID
ALIAS
RAB6
FUSION GENES

Other Information

Locus ID:

NCBI: 5870
MIM: 179513
HGNC: 9786
Ensembl: ENSG00000175582

Variants:

dbSNP: 5870
ClinVar: 5870
TCGA: ENSG00000175582
COSMIC: RAB6A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000175582ENST00000310653P20340
ENSG00000175582ENST00000310653A0A024R5H8
ENSG00000175582ENST00000336083P20340
ENSG00000175582ENST00000336083A0A024R5J5
ENSG00000175582ENST00000536566F5GX61
ENSG00000175582ENST00000537446F5GX61
ENSG00000175582ENST00000540771F5H3K7
ENSG00000175582ENST00000541588P20340
ENSG00000175582ENST00000541973P20340
ENSG00000175582ENST00000545625F5GX61

Expression (GTEx)

0
50
100
150
200
250

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Signal TransductionREACTOMER-HSA-162582
Signaling by NOTCHREACTOMER-HSA-157118
Pre-NOTCH Expression and ProcessingREACTOMER-HSA-1912422
Pre-NOTCH Processing in GolgiREACTOMER-HSA-1912420
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Intra-Golgi and retrograde Golgi-to-ER trafficREACTOMER-HSA-6811442
Retrograde transport at the Trans-Golgi-NetworkREACTOMER-HSA-6811440
Golgi-to-ER retrograde transportREACTOMER-HSA-8856688
COPI-independent Golgi-to-ER retrograde trafficREACTOMER-HSA-6811436
Neutrophil degranulationREACTOMER-HSA-6798695
RAB GEFs exchange GTP for GDP on RABsREACTOMER-HSA-8876198
TBC/RABGAPsREACTOMER-HSA-8854214
RAB geranylgeranylationREACTOMER-HSA-8873719

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
176811402007Rab6 regulates transport and targeting of exocytotic carriers.111
205628652010Rab and actomyosin-dependent fission of transport vesicles at the Golgi complex.104
215965662011Rab6, Rab8, and MICAL3 cooperate in controlling docking and fusion of exocytotic carriers.68
165367382006Rab6A and Rab6A' GTPases play non-overlapping roles in membrane trafficking.55
176995962007Rab6 regulates both ZW10/RINT-1 and conserved oligomeric Golgi complex-dependent Golgi trafficking and homeostasis.43
127388662003Recombinant antibodies to the small GTPase Rab6 as conformation sensors.40
154830562005Regulation of microtubule-dependent recycling at the trans-Golgi network by Rab6A and Rab6A'.35
163953302006A role for the Rab6A' GTPase in the inactivation of the Mad2-spindle checkpoint.34
177168662007Regulation of anterograde transport of adrenergic and angiotensin II receptors by Rab2 and Rab6 GTPases.33
240064912013Identification and characterization of multiple novel Rab-myosin Va interactions.33

Citation

Dessen P

RAB6A (RAB6A, member RAS oncogene family)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/42004/rab6a