Identity
HGNC
LOCATION
7p22.1
LOCUSID
ALIAS
MIG5,MRD48,Rac-1,TC-25,p21-Rac1
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 5879
MIM: 602048
HGNC: 9801
Ensembl: ENSG00000136238
Variants:
dbSNP: 5879
ClinVar: 5879
TCGA: ENSG00000136238
COSMIC: RAC1
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000136238 | ENST00000348035 | P63000 |
| ENSG00000136238 | ENST00000348035 | A4D2P1 |
| ENSG00000136238 | ENST00000356142 | P63000 |
| ENSG00000136238 | ENST00000356142 | A4D2P0 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37540188 | 2024 | LANCL1, a cell surface protein, promotes liver tumor initiation through FAM49B-Rac1 axis to suppress oxidative stress. | 0 |
| 37642813 | 2024 | Circular RNA circ_0058123 Targets the miR-939-5p/RAC1 Pathway to Promote the Development of Colorectal Cancer. | 0 |
| 38141763 | 2024 | The Snail signaling branch downstream of the TGF-β/Smad3 pathway mediates Rho activation and subsequent stress fiber formation. | 3 |
| 38378644 | 2024 | HMGB1 promotes mitochondrial transfer between hepatocellular carcinoma cells through RHOT1 and RAC1 under hypoxia. | 0 |
| 38424547 | 2024 | Tight junction protein cingulin variant is associated with cancer susceptibility by overexpressed IQGAP1 and Rac1-dependent epithelial-mesenchymal transition. | 1 |
| 38508474 | 2024 | PlexinA1 promotes gastric cancer migration through preventing MICAL1 protein ubiquitin/proteasome-mediated degradation in a Rac1-dependent manner. | 0 |
| 37540188 | 2024 | LANCL1, a cell surface protein, promotes liver tumor initiation through FAM49B-Rac1 axis to suppress oxidative stress. | 0 |
| 37642813 | 2024 | Circular RNA circ_0058123 Targets the miR-939-5p/RAC1 Pathway to Promote the Development of Colorectal Cancer. | 0 |
| 38141763 | 2024 | The Snail signaling branch downstream of the TGF-β/Smad3 pathway mediates Rho activation and subsequent stress fiber formation. | 3 |
| 38378644 | 2024 | HMGB1 promotes mitochondrial transfer between hepatocellular carcinoma cells through RHOT1 and RAC1 under hypoxia. | 0 |
| 38424547 | 2024 | Tight junction protein cingulin variant is associated with cancer susceptibility by overexpressed IQGAP1 and Rac1-dependent epithelial-mesenchymal transition. | 1 |
| 38508474 | 2024 | PlexinA1 promotes gastric cancer migration through preventing MICAL1 protein ubiquitin/proteasome-mediated degradation in a Rac1-dependent manner. | 0 |
| 35241625 | 2023 | Epithelial RAC1-dependent cytoskeleton dynamics controls cell mechanics, cell shedding and barrier integrity in intestinal inflammation. | 9 |
| 36054930 | 2023 | A distinct pattern of growth and RAC1 signaling in melanoma brain metastasis cells. | 3 |
| 36446524 | 2023 | Loss of cell-cell adhesion triggers cell migration through Rac1-dependent ROS generation. | 3 |
Citation
Dessen P
RAC1 (Rac family small GTPase 1)
Atlas Genet Cytogenet Oncol Haematol. 2003-02-01
Online version: http://atlasgeneticsoncology.org/gene/42020/rac1
