RAD51B (RAD51 paralog B)

2011-07-01  

Identity

HGNC
LOCATION
14q24.1
LOCUSID
ALIAS
R51H2,RAD51L1,REC2
FUSION GENES

Other Information

Locus ID:

NCBI: 5890
MIM: 602948
HGNC: 9822
Ensembl: ENSG00000182185

Variants:

dbSNP: 5890
ClinVar: 5890
TCGA: ENSG00000182185
COSMIC: RAD51B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000182185ENST00000390683A0A0A0MS18
ENSG00000182185ENST00000471583O15315
ENSG00000182185ENST00000479335F8WAY6
ENSG00000182185ENST00000485181C9J5S9
ENSG00000182185ENST00000487270O15315
ENSG00000182185ENST00000487861C9JYJ0
ENSG00000182185ENST00000488612O15315
ENSG00000182185ENST00000553334G3V4W9
ENSG00000182185ENST00000554575H0YJI5

Expression (GTEx)

0
1
2
3
4
5

Pathways

PathwaySourceExternal ID
Homologous recombinationKEGGko03440
Homologous recombinationKEGGhsa03440
HemostasisREACTOMER-HSA-109582
Factors involved in megakaryocyte development and platelet productionREACTOMER-HSA-983231
DNA RepairREACTOMER-HSA-73894
DNA Double-Strand Break RepairREACTOMER-HSA-5693532
Homology Directed RepairREACTOMER-HSA-5693538
HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)REACTOMER-HSA-5693567
HDR through Homologous Recombination (HRR)REACTOMER-HSA-5685942
Homologous DNA Pairing and Strand ExchangeREACTOMER-HSA-5693579
Presynaptic phase of homologous DNA pairing and strand exchangeREACTOMER-HSA-5693616
Resolution of D-Loop StructuresREACTOMER-HSA-5693537
Resolution of D-loop Structures through Holliday Junction IntermediatesREACTOMER-HSA-5693568
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)REACTOMER-HSA-5693554

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
193300302009A multistage genome-wide association study in breast cancer identifies two new risk alleles at 1p11.2 and 14q24.1 (RAD51L1).294
193300302009A multistage genome-wide association study in breast cancer identifies two new risk alleles at 1p11.2 and 14q24.1 (RAD51L1).294
202373442010Performance of common genetic variants in breast-cancer risk models.191
262612512015Contribution of Germline Mutations in the RAD51B, RAD51C, and RAD51D Genes to Ovarian Cancer in the Population.64
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
124277462003Complex formation by the human Rad51B and Rad51C DNA repair proteins and their activities in vitro.57
224543792012Common breast cancer susceptibility variants in LSP1 and RAD51L1 are associated with mammographic density measures that predict breast cancer risk.50
218522492011Associations of common variants at 1p11.2 and 14q24.1 (RAD51L1) with breast cancer risk and heterogeneity by tumor subtype: findings from the Breast Cancer Association Consortium.44
230011222012Genome-wide association study identifies a common variant in RAD51B associated with male breast cancer risk.39
117446922002RAD51C interacts with RAD51B and is central to a larger protein complex in vivo exclusive of RAD51.33

Citation

Dessen P

RAD51B (RAD51 paralog B)

Atlas Genet Cytogenet Oncol Haematol. 2011-07-01

Online version: http://atlasgeneticsoncology.org/gene/52276/rad51b