RAD54B (RAD54 homolog B)

2003-02-01  

Identity

HGNC
RAD54B
LOCATION
8q22.1
LOCUSID
25788
ALIAS
RDH54
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 25788
MIM: 604289
HGNC: 17228
Ensembl: ENSG00000197275

Variants:

dbSNP: 25788
ClinVar: 25788
TCGA: ENSG00000197275
COSMIC: RAD54B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000197275ENST00000297592Q9Y620
ENSG00000197275ENST00000336148Q9Y620
ENSG00000197275ENST00000463267E5RI14
ENSG00000197275ENST00000518998E5RJF7
ENSG00000197275ENST00000523839E5RHN9

Expression (GTEx)

0
1
2
3
4
5
6
7
8
9
10
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Homologous recombinationKEGGko03440
Homologous recombinationKEGGhsa03440

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
192184312009Specific synthetic lethal killing of RAD54B-deficient human colorectal cancer cells by FEN1 silencing.54
190124932009Common variants in immune and DNA repair genes and risk for human papillomavirus persistence and progression to cervical cancer.41
118846322002Human Rad54B is a double-stranded DNA-dependent ATPase and has biochemical properties different from its structural homolog in yeast, Tid1/Rdh54.23
191245062009Common genetic variation in candidate genes and susceptibility to subtypes of breast cancer.22
257656542015RAD54 family translocases counter genotoxic effects of RAD51 in human tumor cells.17
206878972010Human INO80 chromatin-remodelling complex contributes to DNA double-strand break repair via the expression of Rad54B and XRCC3 genes.15
240026442013Synthetic lethal targeting of superoxide dismutase 1 selectively kills RAD54B-deficient colorectal cancer cells.15
195360922009Explorative study to identify novel candidate genes related to oxaliplatin efficacy and toxicity using a DNA repair array.13
205225372010Variation within DNA repair pathway genes and risk of multiple sclerosis.11
169459622006Stimulation of Dmc1-mediated DNA strand exchange by the human Rad54B protein.10

Citation

Dessen P

RAD54B (RAD54 homolog B)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42030/rad54b