RAET1E (retinoic acid early transcript 1E)

2007-09-01  

Identity

HGNC
LOCATION
6q25.1
LOCUSID
ALIAS
LETAL,N2DL-4,NKG2DL4,RAET1E2,RL-4,ULBP4,bA350J20.7

Other Information

Locus ID:

NCBI: 135250
MIM: 609243
HGNC: 16793
Ensembl: ENSG00000285991

Variants:

dbSNP: 135250
ClinVar: 135250
TCGA: ENSG00000285991
COSMIC: RAET1E

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000285991ENST00000647612A0A3B3IU27

Pathways

PathwaySourceExternal ID
Natural killer cell mediated cytotoxicityKEGGko04650
Natural killer cell mediated cytotoxicityKEGGhsa04650
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellREACTOMER-HSA-198933

References

Pubmed IDYearTitleCitations
194360532009The NKG2D ligand ULBP4 binds to TCRgamma9/delta2 and induces cytotoxicity to tumor cells through both TCRgammadelta and NKG2D.52
152406962004Two human ULBP/RAET1 molecules with transmembrane regions are ligands for NKG2D.51
200548572010ULBP2 and RAET1E NKG2D ligands are independent predictors of poor prognosis in ovarian cancer patients.33
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
174704282007RAET1E2, a soluble isoform of the UL16-binding protein RAET1E produced by tumor cells, inhibits NKG2D-mediated NK cytotoxicity.25
185445722008Four novel ULBP splice variants are ligands for human NKG2D.10
196882092009Polymorphisms of NKG2D ligands: diverse RAET1/ULBP genes in northeastern Thais.8
202196102010Single nucleotide polymorphism analysis of the NKG2D ligand cluster on the long arm of chromosome 6: Extensive polymorphisms and evidence of diversity between human populations.7
202196102010Single nucleotide polymorphism analysis of the NKG2D ligand cluster on the long arm of chromosome 6: Extensive polymorphisms and evidence of diversity between human populations.7
281599272017Decreased expression of the NKG2D ligand ULBP4 may be an indicator of poor prognosis in patients with nasopharyngeal carcinoma.6

Citation

Dessen P

RAET1E (retinoic acid early transcript 1E)

Atlas Genet Cytogenet Oncol Haematol. 2007-09-01

Online version: http://atlasgeneticsoncology.org/gene/49737/raet1e