RALBP1 (ralA binding protein 1)

2003-11-01  

Identity

HGNC
LOCATION
18p11.22
LOCUSID
ALIAS
RIP1,RLIP1,RLIP76
FUSION GENES

Other Information

Locus ID:

NCBI: 10928
MIM: 605801
HGNC: 9841
Ensembl: ENSG00000017797

Variants:

dbSNP: 10928
ClinVar: 10928
TCGA: ENSG00000017797
COSMIC: RALBP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000017797ENST00000019317Q15311
ENSG00000017797ENST00000383432Q15311
ENSG00000017797ENST00000458039E7ENF8
ENSG00000017797ENST00000585015J3QLT3
ENSG00000017797ENST00000609094A0A1W2PRI7

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
Pancreatic cancerKEGGko05212
Pathways in cancerKEGGhsa05200
Pancreatic cancerKEGGhsa05212
Ras signaling pathwayKEGGhsa04014
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
Rho GTPase cycleREACTOMER-HSA-194840

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA448785carbamazepineChemicalPathwayassociated21738081
PA451879vincristineChemicalMultilinkAnnotation, Pathwayassociated27180762

References

Pubmed IDYearTitleCitations
376334692024Abnormal interaction of Rlip with mutant APP/Abeta and phosphorylated tau reduces wild-type Rlip levels and disrupt Rlip function in Alzheimer's disease.0
379263602024The role of RLIP76 in oxidative stress and mitochondrial dysfunction: Evidence based on autopsy brains from Alzheimer's disease patients.0
376334692024Abnormal interaction of Rlip with mutant APP/Abeta and phosphorylated tau reduces wild-type Rlip levels and disrupt Rlip function in Alzheimer's disease.0
379263602024The role of RLIP76 in oxidative stress and mitochondrial dysfunction: Evidence based on autopsy brains from Alzheimer's disease patients.0
353254362022The ABCB1, ABCC2 and RALBP1 polymorphisms are associated with carbamazepine response in epileptic patient: a systematic review.1
359980012022Crucial Role of RLIP76 in Promoting Glycolysis and Tumorigenesis by Stabilization of HIF-1α in Glioma Cells Under Hypoxia.2
353254362022The ABCB1, ABCC2 and RALBP1 polymorphisms are associated with carbamazepine response in epileptic patient: a systematic review.1
359980012022Crucial Role of RLIP76 in Promoting Glycolysis and Tumorigenesis by Stabilization of HIF-1α in Glioma Cells Under Hypoxia.2
334607252021Activating p53 function by targeting RLIP.2
335449362021Prevention of mammary carcinogenesis in MMTV-neu mice by targeting RLIP.2
336239912021RLIP depletion induces apoptosis associated with inhibition of JAK2/STAT3 signaling in melanoma cells.1
334607252021Activating p53 function by targeting RLIP.2
335449362021Prevention of mammary carcinogenesis in MMTV-neu mice by targeting RLIP.2
336239912021RLIP depletion induces apoptosis associated with inhibition of JAK2/STAT3 signaling in melanoma cells.1
317464082020Increased RLIP76 expression in IDH1 wild‑type glioblastoma multiforme is associated with worse prognosis.4

Citation

Dessen P

RALBP1 (ralA binding protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/42037/ralbp1