RAMP1 (receptor activity modifying protein 1)

2014-03-01  

Identity

HGNC
LOCATION
2q37.3
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 10267
MIM: 605153
HGNC: 9843
Ensembl: ENSG00000132329

Variants:

dbSNP: 10267
ClinVar: 10267
TCGA: ENSG00000132329
COSMIC: RAMP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000132329ENST00000254661O60894
ENSG00000132329ENST00000403885E9PC20
ENSG00000132329ENST00000404910E9PC20
ENSG00000132329ENST00000409726E9PC20

Expression (GTEx)

0
100
200
300
400
500
600
700
800
900
1000

Pathways

PathwaySourceExternal ID
Vascular smooth muscle contractionKEGGhsa04270
Vascular smooth muscle contractionKEGGko04270
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class B/2 (Secretin family receptors)REACTOMER-HSA-373080
Calcitonin-like ligand receptorsREACTOMER-HSA-419812
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (s) signalling eventsREACTOMER-HSA-418555

References

Pubmed IDYearTitleCitations
118472132002Receptor activity-modifying protein 1 determines the species selectivity of non-peptide CGRP receptor antagonists.37
259821132015Structural Basis for Receptor Activity-Modifying Protein-Dependent Selective Peptide Recognition by a G Protein-Coupled Receptor.35
302094002018Cryo-EM structure of the active, Gs-protein complexed, human CGRP receptor.34
119734352002Immunohistochemical localization of calcitonin receptor-like receptor and receptor activity-modifying proteins in the human cerebral vasculature.33
177854632007Functional calcitonin gene-related peptide receptors are formed by the asymmetric assembly of a calcitonin receptor-like receptor homo-oligomer and a monomer of receptor activity-modifying protein-1.31
156134682005Novel function for receptor activity-modifying proteins (RAMPs) in post-endocytic receptor trafficking.29
173100672007Post-endocytic sorting of calcitonin receptor-like receptor and receptor activity-modifying protein 1.29
201009892010Receptor activity-modifying protein 1 increases baroreflex sensitivity and attenuates Angiotensin-induced hypertension.23
185938222008Identification of N-terminal receptor activity-modifying protein residues important for calcitonin gene-related peptide, adrenomedullin, and amylin receptor function.20
187254562008Crystal structure of the human receptor activity-modifying protein 1 extracellular domain.16

Citation

Dessen P

RAMP1 (receptor activity modifying protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-03-01

Online version: http://atlasgeneticsoncology.org/gene/53840/ramp1