RAMP2 (receptor activity modifying protein 2)

2007-11-01  

Identity

HGNC
LOCATION
17q21.2
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 10266
MIM: 605154
HGNC: 9844
Ensembl: ENSG00000131477

Variants:

dbSNP: 10266
ClinVar: 10266
TCGA: ENSG00000131477
COSMIC: RAMP2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000131477ENST00000253796O60895
ENSG00000131477ENST00000253796A0A024R1Z2
ENSG00000131477ENST00000587142O60895
ENSG00000131477ENST00000588576K7EKQ3
ENSG00000131477ENST00000588928K7ENJ8
ENSG00000131477ENST00000589683K7EPN3

Expression (GTEx)

0
50
100
150
200
250
300

Pathways

PathwaySourceExternal ID
Vascular smooth muscle contractionKEGGhsa04270
Vascular smooth muscle contractionKEGGko04270
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class B/2 (Secretin family receptors)REACTOMER-HSA-373080
Calcitonin-like ligand receptorsREACTOMER-HSA-419812
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (s) signalling eventsREACTOMER-HSA-418555

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
259821132015Structural Basis for Receptor Activity-Modifying Protein-Dependent Selective Peptide Recognition by a G Protein-Coupled Receptor.35
119734352002Immunohistochemical localization of calcitonin receptor-like receptor and receptor activity-modifying proteins in the human cerebral vasculature.33
176711142007Frequent inactivation of RAMP2, EFEMP1 and Dutt1 in lung cancer by promoter hypermethylation.32
156134682005Novel function for receptor activity-modifying proteins (RAMPs) in post-endocytic receptor trafficking.29
221023692012Structural basis for extracellular interactions between calcitonin receptor-like receptor and receptor activity-modifying protein 2 for adrenomedullin-specific binding.24
261986342015Modulation of Glucagon Receptor Pharmacology by Receptor Activity-modifying Protein-2 (RAMP2).22
185938222008Identification of N-terminal receptor activity-modifying protein residues important for calcitonin gene-related peptide, adrenomedullin, and amylin receptor function.20
270136572016Receptor Activity-modifying Proteins 2 and 3 Generate Adrenomedullin Receptor Subtypes with Distinct Molecular Properties.18
241996272014Receptor activity-modifying protein-dependent effects of mutations in the calcitonin receptor-like receptor: implications for adrenomedullin and calcitonin gene-related peptide pharmacology.15

Citation

Dessen P

RAMP2 (receptor activity modifying protein 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-11-01

Online version: http://atlasgeneticsoncology.org/gene/49831/ramp2