Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 57826
MIM: 301016
HGNC: 21165
Ensembl: ENSG00000123728
Variants:
dbSNP: 57826
ClinVar: 57826
TCGA: ENSG00000123728
COSMIC: RAP2C
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000123728 | ENST00000342983 | Q9Y3L5 |
| ENSG00000123728 | ENST00000370874 | Q9Y3L5 |
| ENSG00000123728 | ENST00000620646 | A0A087X2C3 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Tight junction | KEGG | ko04530 |
| Tight junction | KEGG | hsa04530 |
| Immune System | REACTOME | R-HSA-168256 |
| Innate Immune System | REACTOME | R-HSA-168249 |
| Neutrophil degranulation | REACTOME | R-HSA-6798695 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36214632 | 2022 | The LncRNA LENOX Interacts with RAP2C to Regulate Metabolism and Promote Resistance to MAPK Inhibition in Melanoma. | 6 |
| 36214632 | 2022 | The LncRNA LENOX Interacts with RAP2C to Regulate Metabolism and Promote Resistance to MAPK Inhibition in Melanoma. | 6 |
| 34676879 | 2021 | MicroRNA‑200c‑3p suppresses intervertebral disc degeneration by targeting RAP2C/ERK signaling. | 3 |
| 34676879 | 2021 | MicroRNA‑200c‑3p suppresses intervertebral disc degeneration by targeting RAP2C/ERK signaling. | 3 |
| 31541458 | 2020 | MicroRNA-188-5p promotes apoptosis and inhibits cell proliferation of breast cancer cells via the MAPK signaling pathway by targeting Rap2c. | 30 |
| 33302819 | 2020 | microRNA-195 Promotes Small Cell Lung Cancer Cell Apoptosis via Inhibiting Rap2C Protein-Dependent MAPK Signal Transduction. | 5 |
| 31541458 | 2020 | MicroRNA-188-5p promotes apoptosis and inhibits cell proliferation of breast cancer cells via the MAPK signaling pathway by targeting Rap2c. | 30 |
| 33302819 | 2020 | microRNA-195 Promotes Small Cell Lung Cancer Cell Apoptosis via Inhibiting Rap2C Protein-Dependent MAPK Signal Transduction. | 5 |
| 28714326 | 2017 | Spinal cord ischemia-reperfusion causes damage of neurocyte by inhibiting RAP2C. | 6 |
| 28714326 | 2017 | Spinal cord ischemia-reperfusion causes damage of neurocyte by inhibiting RAP2C. | 6 |
| 23885123 | 2013 | JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function. | 73 |
| 23885123 | 2013 | JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function. | 73 |
| 17447155 | 2007 | Cloning and characterization of the human gene RAP2C, a novel member of Ras family, which activates transcriptional activities of SRE. | 8 |
| 17447155 | 2007 | Cloning and characterization of the human gene RAP2C, a novel member of Ras family, which activates transcriptional activities of SRE. | 8 |
| 16213650 | 2006 | Identification and biochemical characterization of Rap2C, a new member of the Rap family of small GTP-binding proteins. | 20 |
Citation
Dessen P
RAP2C (RAP2C, member of RAS oncogene family)
Atlas Genet Cytogenet Oncol Haematol. 2003-12-01
Online version: http://atlasgeneticsoncology.org/gene/42044/rap2c
