RAP2C (RAP2C, member of RAS oncogene family)

2003-12-01 Affiliation

Identity

HGNC

RAP2C

LOCATION

Xq26.2

LOCUSID

57826

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 57826
MIM: 301016
HGNC: 21165
Ensembl: ENSG00000123728

Variants:

dbSNP: 57826
ClinVar: 57826
TCGA: ENSG00000123728
COSMIC: RAP2C

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000123728	ENST00000342983	Q9Y3L5
ENSG00000123728	ENST00000370874	Q9Y3L5
ENSG00000123728	ENST00000620646	A0A087X2C3

Expression (GTEx)

100

150

200

250

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Tight junction	KEGG	ko04530
Tight junction	KEGG	hsa04530
Immune System	REACTOME	R-HSA-168256
Innate Immune System	REACTOME	R-HSA-168249
Neutrophil degranulation	REACTOME	R-HSA-6798695

References

Pubmed ID	Year	Title	Citations
23885123	2013	JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function.	44
16213650	2006	Identification and biochemical characterization of Rap2C, a new member of the Rap family of small GTP-binding proteins.	16
17447155	2007	Cloning and characterization of the human gene RAP2C, a novel member of Ras family, which activates transcriptional activities of SRE.	4
28714326	2017	Spinal cord ischemia-reperfusion causes damage of neurocyte by inhibiting RAP2C.	3

Citation

Dessen P

RAP2C (RAP2C, member of RAS oncogene family)

Atlas Genet Cytogenet Oncol Haematol. 2003-12-01

Online version: http://atlasgeneticsoncology.org/gene/42044/rap2c