RAPGEF2 (Rap guanine nucleotide exchange factor 2)

2003-11-01 Affiliation

Identity

HGNC

RAPGEF2

LOCATION

4q32.1

LOCUSID

9693

ALIAS

CNrasGEF,NRAPGEP,PDZ-GEF1,PDZGEF1,RA-GEF,RA-GEF-1,RAGEF,Rap-GEP,nRap

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 9693
MIM: 609530
HGNC: 16854
Ensembl: ENSG00000109756

Variants:

dbSNP: 9693
ClinVar: 9693
TCGA: ENSG00000109756
COSMIC: RAPGEF2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000109756	ENST00000264431	Q9Y4G8
ENSG00000109756	ENST00000502485	H0Y8T6
ENSG00000109756	ENST00000505026	H0YAJ8
ENSG00000109756	ENST00000505478	H0Y905
ENSG00000109756	ENST00000510253	H0Y8H7
ENSG00000109756	ENST00000510510	D6RAK0
ENSG00000109756	ENST00000511336	D6REY8
ENSG00000109756	ENST00000512056	H0Y8N8
ENSG00000109756	ENST00000514565	D6RC78
ENSG00000109756	ENST00000644474	A0A2R8YGD3
ENSG00000109756	ENST00000644902	A0A2R8Y661

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
MAPK signaling pathway	KEGG	ko04010
Tight junction	KEGG	ko04530
MAPK signaling pathway	KEGG	hsa04010
Tight junction	KEGG	hsa04530
Rap1 signaling pathway	KEGG	hsa04015
Rap1 signaling pathway	KEGG	ko04015
Immune System	REACTOME	R-HSA-168256
Innate Immune System	REACTOME	R-HSA-168249
DAP12 interactions	REACTOME	R-HSA-2172127
DAP12 signaling	REACTOME	R-HSA-2424491
RAF/MAP kinase cascade	REACTOME	R-HSA-5673001
Fc epsilon receptor (FCERI) signaling	REACTOME	R-HSA-2454202
FCERI mediated MAPK activation	REACTOME	R-HSA-2871796
Cytokine Signaling in Immune system	REACTOME	R-HSA-1280215
Signaling by Interleukins	REACTOME	R-HSA-449147
Interleukin-2 signaling	REACTOME	R-HSA-451927
Interleukin receptor SHC signaling	REACTOME	R-HSA-912526
Interleukin-3, 5 and GM-CSF signaling	REACTOME	R-HSA-512988
Signal Transduction	REACTOME	R-HSA-162582
Signaling by EGFR	REACTOME	R-HSA-177929
GRB2 events in EGFR signaling	REACTOME	R-HSA-179812
SHC1 events in EGFR signaling	REACTOME	R-HSA-180336
Signaling by Insulin receptor	REACTOME	R-HSA-74752
Insulin receptor signalling cascade	REACTOME	R-HSA-74751
IRS-mediated signalling	REACTOME	R-HSA-112399
SOS-mediated signalling	REACTOME	R-HSA-112412
Signalling by NGF	REACTOME	R-HSA-166520
NGF signalling via TRKA from the plasma membrane	REACTOME	R-HSA-187037
Signalling to ERKs	REACTOME	R-HSA-187687
Signalling to RAS	REACTOME	R-HSA-167044
Signalling to p38 via RIT and RIN	REACTOME	R-HSA-187706
Prolonged ERK activation events	REACTOME	R-HSA-169893
Frs2-mediated activation	REACTOME	R-HSA-170968
ARMS-mediated activation	REACTOME	R-HSA-170984
Signaling by PDGF	REACTOME	R-HSA-186797
Downstream signal transduction	REACTOME	R-HSA-186763
Signaling by VEGF	REACTOME	R-HSA-194138
VEGFA-VEGFR2 Pathway	REACTOME	R-HSA-4420097
VEGFR2 mediated cell proliferation	REACTOME	R-HSA-5218921
Signaling by SCF-KIT	REACTOME	R-HSA-1433557
MAPK family signaling cascades	REACTOME	R-HSA-5683057
MAPK1/MAPK3 signaling	REACTOME	R-HSA-5684996
Signaling by GPCR	REACTOME	R-HSA-372790
Gastrin-CREB signalling pathway via PKC and MAPK	REACTOME	R-HSA-881907
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	REACTOME	R-HSA-2404192
IGF1R signaling cascade	REACTOME	R-HSA-2428924
IRS-related events triggered by IGF1R	REACTOME	R-HSA-2428928
Signaling by Leptin	REACTOME	R-HSA-2586552
Developmental Biology	REACTOME	R-HSA-1266738
Axon guidance	REACTOME	R-HSA-422475
NCAM signaling for neurite out-growth	REACTOME	R-HSA-375165
RET signaling	REACTOME	R-HSA-8853659

References

Pubmed ID	Year	Title	Citations
12196628	2002	The semaphorin receptor plexin-B1 signals through a direct interaction with the Rho-specific nucleotide exchange factor, LARG.	63
11799111	2002	Regulation of G protein-linked guanine nucleotide exchange factors for Rho, PDZ-RhoGEF, and LARG by tyrosine phosphorylation: evidence of a role for focal adhesion kinase.	52
23885123	2013	JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function.	44
17724123	2007	Rap1-PDZ-GEF1 interacts with a neurotrophin receptor at late endosomes, leading to sustained activation of Rap1 and ERK and neurite outgrowth.	40
22422452	2012	DNA methylation shows genome-wide association of NFIX, RAPGEF2 and MSRB3 with gestational age at birth.	33
21840392	2011	Epac1 and PDZ-GEF cooperate in Rap1 mediated endothelial junction control.	31
25332235	2015	Substrate trapping proteomics reveals targets of the βTrCP2/FBXW11 ubiquitin ligase.	26
23800469	2013	Rapgef2 connects GPCR-mediated cAMP signals to ERK activation in neuronal and endocrine cells.	25
25189171	2014	Cdk5-mediated phosphorylation of RapGEF2 controls neuronal migration in the developing cerebral cortex.	25
24290981	2013	Control of epithelial cell migration and invasion by the IKKβ- and CK1α-mediated degradation of RAPGEF2.	15

Citation

Dessen P

RAPGEF2 (Rap guanine nucleotide exchange factor 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/42046/rapgef2