RAPGEF3 (Rap guanine nucleotide exchange factor 3)

2006-10-01 Affiliation

Identity

HGNC

RAPGEF3

LOCATION

12q13.11

LOCUSID

10411

ALIAS

CAMP-GEFI,EPAC,EPAC1,HSU79275,bcm910

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 10411
MIM: 606057
HGNC: 16629
Ensembl: ENSG00000079337

Variants:

dbSNP: 10411
ClinVar: 10411
TCGA: ENSG00000079337
COSMIC: RAPGEF3

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000079337	ENST00000389212	O95398
ENSG00000079337	ENST00000395358	O95398
ENSG00000079337	ENST00000405493	O95398
ENSG00000079337	ENST00000449771	O95398
ENSG00000079337	ENST00000466322	F8W0N0
ENSG00000079337	ENST00000495465	H0YIP6
ENSG00000079337	ENST00000495953	F8VXK1
ENSG00000079337	ENST00000547856	F8VVJ6
ENSG00000079337	ENST00000548434	H0YHS2
ENSG00000079337	ENST00000548919	F8VRX1
ENSG00000079337	ENST00000549151	O95398

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Leukocyte transendothelial migration	KEGG	ko04670
Long-term potentiation	KEGG	ko04720
Leukocyte transendothelial migration	KEGG	hsa04670
Long-term potentiation	KEGG	hsa04720
Serotonergic synapse	KEGG	hsa04726
Rap1 signaling pathway	KEGG	hsa04015
Rap1 signaling pathway	KEGG	ko04015
Adrenergic signaling in cardiomyocytes	KEGG	hsa04261
Adrenergic signaling in cardiomyocytes	KEGG	ko04261
cAMP signaling pathway	KEGG	hsa04024
cAMP signaling pathway	KEGG	ko04024
Immune System	REACTOME	R-HSA-168256
Adaptive Immune System	REACTOME	R-HSA-1280218
Rap1 signalling	REACTOME	R-HSA-392517
Hemostasis	REACTOME	R-HSA-109582
Platelet activation, signaling and aggregation	REACTOME	R-HSA-76002
Platelet Aggregation (Plug Formation)	REACTOME	R-HSA-76009
Integrin alphaIIb beta3 signaling	REACTOME	R-HSA-354192
Signal Transduction	REACTOME	R-HSA-162582
Metabolism	REACTOME	R-HSA-1430728
Integration of energy metabolism	REACTOME	R-HSA-163685
Regulation of insulin secretion	REACTOME	R-HSA-422356
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	REACTOME	R-HSA-381676
Phospholipase D signaling pathway	KEGG	ko04072
Phospholipase D signaling pathway	KEGG	hsa04072

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
15545605	2004	Fluorescent indicators of cAMP and Epac activation reveal differential dynamics of cAMP signaling within discrete subcellular compartments.	185
15601837	2005	Cyclic AMP potentiates vascular endothelial cadherin-mediated cell-cell contact to enhance endothelial barrier function through an Epac-Rap1 signaling pathway.	169
15374886	2005	Regulation of vascular endothelial barrier function by Epac, a cAMP-activated exchange factor for Rap GTPase.	158
16115630	2005	Epac1 regulates integrity of endothelial cell junctions through VE-cadherin.	129
11801596	2002	Differential signaling of cyclic AMP: opposing effects of exchange protein directly activated by cyclic AMP and cAMP-dependent protein kinase on protein kinase B activation.	88
17599964	2007	The cAMP binding protein Epac modulates Ca2+ sparks by a Ca2+/calmodulin kinase signalling pathway in rat cardiac myocytes.	79
18323524	2008	Epac mediates beta-adrenergic receptor-induced cardiomyocyte hypertrophy.	79
15166221	2004	Rap1 regulates E-cadherin-mediated cell-cell adhesion.	78
12000763	2002	Cell cycle-dependent subcellular localization of exchange factor directly activated by cAMP.	73
24316969	2014	Increased sugar uptake promotes oncogenesis via EPAC/RAP1 and O-GlcNAc pathways.	65

Citation

Dessen P

RAPGEF3 (Rap guanine nucleotide exchange factor 3)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43445/rapgef3