RARG (retinoic acid receptor gamma)

2003-05-01  

Identity

HGNC
LOCATION
12q13.13
LOCUSID
ALIAS
NR1B3,RARC
FUSION GENES

Other Information

Locus ID:

NCBI: 5916
MIM: 180190
HGNC: 9866
Ensembl: ENSG00000172819

Variants:

dbSNP: 5916
ClinVar: 5916
TCGA: ENSG00000172819
COSMIC: RARG

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000172819ENST00000338561P13631
ENSG00000172819ENST00000338561F1D8P1
ENSG00000172819ENST00000394426P13631
ENSG00000172819ENST00000425354P13631
ENSG00000172819ENST00000425354A8K3H3
ENSG00000172819ENST00000543726P13631
ENSG00000172819ENST00000546717H3BMK1
ENSG00000172819ENST00000550362H3BMH6
ENSG00000172819ENST00000551158H3BMY6

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by Retinoic AcidREACTOMER-HSA-5362517
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Nuclear Receptor transcription pathwayREACTOMER-HSA-383280
Developmental BiologyREACTOMER-HSA-1266738
Activation of HOX genes during differentiationREACTOMER-HSA-5619507
Activation of anterior HOX genes in hindbrain development during early embryogenesisREACTOMER-HSA-5617472

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA130620651anthracyclines and related substancesChemicalClinicalAnnotationassociatedPD
PA166128121cardiotoxicityDiseaseClinicalAnnotationassociatedPD
PA445062NeoplasmsDiseaseClinicalAnnotationassociatedPD
PA449212daunorubicinChemicalGuidelineAnnotationassociated
PA449412doxorubicinChemicalGuidelineAnnotationassociated

References

Pubmed IDYearTitleCitations
195637582009Genomic antagonism between retinoic acid and estrogen signaling in breast cancer.122
219903482011Rapid and efficient reprogramming of somatic cells to induced pluripotent stem cells by retinoic acid receptor gamma and liver receptor homolog 1.102
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
199022552010Rubella vaccine-induced cellular immunity: evidence of associations with polymorphisms in the Toll-like, vitamin A and D receptors, and innate immune response genes.53
199022552010Rubella vaccine-induced cellular immunity: evidence of associations with polymorphisms in the Toll-like, vitamin A and D receptors, and innate immune response genes.53
262374292015A coding variant in RARG confers susceptibility to anthracycline-induced cardiotoxicity in childhood cancer.51
121895562002Retinoids cause apoptosis in pancreatic cancer cells via activation of RAR-gamma and altered expression of Bcl-2/Bax.40
211780082011Restricted microbiota and absence of cognate TCR antigen leads to an unbalanced generation of Th17 cells.29
173250342007CSK controls retinoic acid receptor (RAR) signaling: a RAR-c-SRC signaling axis is required for neuritogenic differentiation.25
237985552013Oncogenic activity of retinoic acid receptor γ is exhibited through activation of the Akt/NF-κB and Wnt/β-catenin pathways in cholangiocarcinoma.24

Citation

Dessen P

RARG (retinoic acid receptor gamma)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/42049/rarg