Atlas of Genetics and Cytogenetics in Oncology and Haematology


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RARS1 (arginyl-tRNA synthetase 1)

Identity

Alias_namesRARS
arginyl-tRNA synthetase
Alias_symbol (synonym)DALRD1
Other aliasArgRS
HLD9
HGNC (Hugo) RARS1
LocusID (NCBI) 5917
Atlas_Id 54573
Location 5q34  [Link to chromosome band 5q34]
Location_base_pair Starts at 168486458 and ends at 168519304 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(5;7)(q34;p22) RARS/MAD1L1


External links

Nomenclature
HGNC (Hugo)RARS1   9870
Cards
Entrez_Gene (NCBI)RARS1  5917  arginyl-tRNA synthetase 1
AliasesArgRS; DALRD1; HLD9; RARS
GeneCards (Weizmann)RARS1
Ensembl hg19 (Hinxton)ENSG00000113643 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000113643 [Gene_View]  ENSG00000113643 [Sequence]  chr5:168486458-168519304 [Contig_View]  RARS1 [Vega]
ICGC DataPortalENSG00000113643
TCGA cBioPortalRARS1
AceView (NCBI)RARS1
Genatlas (Paris)RARS1
WikiGenes5917
SOURCE (Princeton)RARS1
Genetics Home Reference (NIH)RARS1
Genomic and cartography
GoldenPath hg38 (UCSC)RARS1  -     chr5:168486458-168519304 +  -   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RARS1  -     -   [Description]    (hg19-Feb_2009)
GoldenPathRARS1 - - [CytoView hg19]  RARS1 - - [CytoView hg38]
ImmunoBaseENSG00000113643
Mapping of homologs : NCBIRARS1 [Mapview hg19]  RARS1 [Mapview hg38]
OMIM107820   616140   
Gene and transcription
Genbank (Entrez)AK222797 AK302161 AK314795 AU125370 BC000528
RefSeq transcript (Entrez)NM_002887
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)RARS1
Cluster EST : UnigeneHs.654907 [ NCBI ]
CGAP (NCI)Hs.654907
Alternative Splicing GalleryENSG00000113643
Gene ExpressionRARS1 [ NCBI-GEO ]   RARS1 [ EBI - ARRAY_EXPRESS ]   RARS1 [ SEEK ]   RARS1 [ MEM ]
Gene Expression Viewer (FireBrowse)RARS1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5917
GTEX Portal (Tissue expression)RARS1
Human Protein AtlasENSG00000113643-RARS1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP54136   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP54136  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP54136
Splice isoforms : SwissVarP54136
Catalytic activity : Enzyme6.1.1.19 [ Enzyme-Expasy ]   6.1.1.196.1.1.19 [ IntEnz-EBI ]   6.1.1.19 [ BRENDA ]   6.1.1.19 [ KEGG ]   
PhosPhoSitePlusP54136
Domaine pattern : Prosite (Expaxy)AA_TRNA_LIGASE_I (PS00178)   
Domains : Interpro (EBI)aa-tRNA-synth_I_CS    Arg-tRNA-ligase    Arg-tRNA-synth_N    Arg-tRNA-synth_N_sf    ArgRS_core    DALR_anticod-bd    Rossmann-like_a/b/a_fold    tRNAsynth_Ia_anticodon-bd   
Domain families : Pfam (Sanger)Arg_tRNA_synt_N (PF03485)    DALR_1 (PF05746)    tRNA-synt_1d (PF00750)   
Domain families : Pfam (NCBI)pfam03485    pfam05746    pfam00750   
Domain families : Smart (EMBL)Arg_tRNA_synt_N (SM01016)  DALR_1 (SM00836)  
Conserved Domain (NCBI)RARS1
DMDM Disease mutations5917
Blocks (Seattle)RARS1
PDB (RSDB)4Q2T    4Q2X    4Q2Y    4R3Z    4ZAJ   
PDB Europe4Q2T    4Q2X    4Q2Y    4R3Z    4ZAJ   
PDB (PDBSum)4Q2T    4Q2X    4Q2Y    4R3Z    4ZAJ   
PDB (IMB)4Q2T    4Q2X    4Q2Y    4R3Z    4ZAJ   
Structural Biology KnowledgeBase4Q2T    4Q2X    4Q2Y    4R3Z    4ZAJ   
SCOP (Structural Classification of Proteins)4Q2T    4Q2X    4Q2Y    4R3Z    4ZAJ   
CATH (Classification of proteins structures)4Q2T    4Q2X    4Q2Y    4R3Z    4ZAJ   
SuperfamilyP54136
Human Protein Atlas [tissue]ENSG00000113643-RARS1 [tissue]
Peptide AtlasP54136
HPRD00142
IPIIPI00004860   IPI00759723   IPI01018632   IPI00984107   IPI00974264   IPI00973800   
Protein Interaction databases
DIP (DOE-UCLA)P54136
IntAct (EBI)P54136
FunCoupENSG00000113643
BioGRIDRARS1
STRING (EMBL)RARS1
ZODIACRARS1
Ontologies - Pathways
QuickGOP54136
Ontology : AmiGOtRNA binding  arginine-tRNA ligase activity  arginine-tRNA ligase activity  arginine-tRNA ligase activity  protein binding  ATP binding  nucleus  nucleoplasm  cytoplasm  cytosol  cytosol  tRNA aminoacylation for protein translation  arginyl-tRNA aminoacylation  arginyl-tRNA aminoacylation  membrane  aminoacyl-tRNA synthetase multienzyme complex  arginine binding  cadherin binding  extracellular exosome  
Ontology : EGO-EBItRNA binding  arginine-tRNA ligase activity  arginine-tRNA ligase activity  arginine-tRNA ligase activity  protein binding  ATP binding  nucleus  nucleoplasm  cytoplasm  cytosol  cytosol  tRNA aminoacylation for protein translation  arginyl-tRNA aminoacylation  arginyl-tRNA aminoacylation  membrane  aminoacyl-tRNA synthetase multienzyme complex  arginine binding  cadherin binding  extracellular exosome  
NDEx NetworkRARS1
Atlas of Cancer Signalling NetworkRARS1
Wikipedia pathwaysRARS1
Orthology - Evolution
OrthoDB5917
GeneTree (enSembl)ENSG00000113643
Phylogenetic Trees/Animal Genes : TreeFamRARS1
HOGENOMP54136
Homologs : HomoloGeneRARS1
Homology/Alignments : Family Browser (UCSC)RARS1
Gene fusions - Rearrangements
Fusion : MitelmanRARS/MAD1L1 [5q34/7p22.3]  
Fusion : QuiverRARS1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRARS1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RARS1
dbVarRARS1
ClinVarRARS1
1000_GenomesRARS1 
Exome Variant ServerRARS1
ExAC (Exome Aggregation Consortium)ENSG00000113643
GNOMAD BrowserENSG00000113643
Varsome BrowserRARS1
Genetic variants : HAPMAP5917
Genomic Variants (DGV)RARS1 [DGVbeta]
DECIPHERRARS1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRARS1 
Mutations
ICGC Data PortalRARS1 
TCGA Data PortalRARS1 
Broad Tumor PortalRARS1
OASIS PortalRARS1 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDRARS1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch RARS1
DgiDB (Drug Gene Interaction Database)RARS1
DoCM (Curated mutations)RARS1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RARS1 (select a term)
intoGenRARS1
Cancer3DRARS1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM107820    616140   
Orphanet23363   
DisGeNETRARS1
MedgenRARS1
Genetic Testing Registry RARS1
NextProtP54136 [Medical]
TSGene5917
GENETestsRARS1
Target ValidationRARS1
Huge Navigator RARS1 [HugePedia]
snp3D : Map Gene to Disease5917
BioCentury BCIQRARS1
ClinGenRARS1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5917
Chemical/Pharm GKB GenePA34231
Clinical trialRARS1
Miscellaneous
canSAR (ICR)RARS1 (select the gene name)
DataMed IndexRARS1
Probes
Litterature
PubMed112 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRARS1
EVEXRARS1
GoPubMedRARS1
iHOPRARS1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Nov 13 18:04:12 CET 2019

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