RASSF4 (Ras association domain family member 4)

2003-10-01  

Identity

HGNC
LOCATION
10q11.21
LOCUSID
ALIAS
AD037
FUSION GENES

Other Information

Locus ID:

NCBI: 83937
MIM: 610559
HGNC: 20793
Ensembl: ENSG00000107551

Variants:

dbSNP: 83937
ClinVar: 83937
TCGA: ENSG00000107551
COSMIC: RASSF4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000107551ENST00000340258Q9H2L5
ENSG00000107551ENST00000427758Q5T739
ENSG00000107551ENST00000428466Q5T737
ENSG00000107551ENST00000483709R4GNA4
ENSG00000107551ENST00000484477V9GYK1

Expression (GTEx)

0
50
100
150
200
250

Pathways

PathwaySourceExternal ID
Hippo signaling pathway -multiple speciesKEGGko04392
Hippo signaling pathway -multiple speciesKEGGhsa04392

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
163854512006A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.69
190663932009Acquired variation outweighs inherited variation in whole genome analysis of methotrexate polyglutamate accumulation in leukemia.22
286004352017RASSF4 controls SOCE and ER-PM junctions through regulation of PI(4,5)P2.17
173737002007Association studies of 23 positional/functional candidate genes on chromosome 10 in late-onset Alzheimer's disease.15
265265762016RASSF4 is downregulated in nonsmall cell lung cancer and inhibits cancer cell proliferation and invasion.7
292590092018Loss of RASSF4 Expression in Multiple Myeloma Promotes RAS-Driven Malignant Progression.7
239546382013Small proline-rich protein-1B is overexpressed in human oral squamous cell cancer stem-like cells and is related to their growth through activation of MAP kinase signal.6
280817362017RASSF4 Overexpression Inhibits the Proliferation, Invasion, EMT, and Wnt Signaling Pathway in Osteosarcoma Cells.6
257017842015RASSF4 promotes EV71 replication to accelerate the inhibition of the phosphorylation of AKT.3

Citation

Dessen P

RASSF4 (Ras association domain family member 4)

Atlas Genet Cytogenet Oncol Haematol. 2003-10-01

Online version: http://atlasgeneticsoncology.org/gene/42058/rassf4