RBBP6 (RB binding protein 6, ubiquitin ligase)

2003-08-01  

Identity

HGNC
RBBP6
LOCATION
16p12.1
LOCUSID
5930
ALIAS
MY038,P2P-R,PACT,RBQ-1,SNAMA
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 5930
MIM: 600938
HGNC: 9889
Ensembl: ENSG00000122257

Variants:

dbSNP: 5930
ClinVar: 5930
TCGA: ENSG00000122257
COSMIC: RBBP6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000122257ENST00000319715Q7Z6E9
ENSG00000122257ENST00000348022Q7Z6E9
ENSG00000122257ENST00000381039Q7Z6E9
ENSG00000122257ENST00000452655Q7Z6E9
ENSG00000122257ENST00000562683A0A087WY32
ENSG00000122257ENST00000564314H3BSK8
ENSG00000122257ENST00000567686H3BUN0
ENSG00000122257ENST00000568015I3L3Y2
ENSG00000122257ENST00000646282A0A2R8Y880

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
221630342011The role of Dicer protein partners in the processing of microRNA precursors.46
188519792008RBBP6 interacts with multifunctional protein YB-1 through its RING finger domain, leading to ubiquitination and proteosomal degradation of YB-1.27
247263592014The RBBP6/ZBTB38/MCM10 axis regulates DNA replication and common fragile site stability.26
253198262014RBBP6 isoforms regulate the human polyadenylation machinery and modulate expression of mRNAs with AU-rich 3' UTRs.26
163966802006DWNN, a novel ubiquitin-like domain, implicates RBBP6 in mRNA processing and ubiquitin-like pathways.25
305507892018Protein Interaction Mapping Identifies RBBP6 as a Negative Regulator of Ebola Virus Replication.20
262882492015Variability of Gene Expression Identifies Transcriptional Regulators of Early Human Embryonic Development.17
216764862011Expression and function of retinoblastoma binding protein 6 (RBBP6) in human lung cancer.13
221393012012De-regulation of the RBBP6 isoform 3/DWNN in human cancers.11
247031062014Silencing RBBP6 (Retinoblastoma Binding Protein 6) sensitises breast cancer cells MCF7 to staurosporine and camptothecin-induced cell death.11

Citation

Dessen P

RBBP6 (RB binding protein 6, ubiquitin ligase)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/42064/rbbp6