RDX (radixin)

2009-03-01  

Identity

HGNC
LOCATION
11q22.3
LOCUSID
ALIAS
DFNB24
FUSION GENES

Other Information

Locus ID:

NCBI: 5962
MIM: 179410
HGNC: 9944
Ensembl: ENSG00000137710

Variants:

dbSNP: 5962
ClinVar: 5962
TCGA: ENSG00000137710
COSMIC: RDX

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000137710ENST00000528498P35241
ENSG00000137710ENST00000528556E9PN07
ENSG00000137710ENST00000528900P35241
ENSG00000137710ENST00000530131E9PNP4
ENSG00000137710ENST00000530301P35241
ENSG00000137710ENST00000530749P35241
ENSG00000137710ENST00000532118E9PNV3
ENSG00000137710ENST00000533678E9PRS5
ENSG00000137710ENST00000533991E9PQ82
ENSG00000137710ENST00000534683E9PKN5
ENSG00000137710ENST00000544551P35241
ENSG00000137710ENST00000642511A0A2R8Y5P0
ENSG00000137710ENST00000645312A0A2R8Y4H6
ENSG00000137710ENST00000645495P35241
ENSG00000137710ENST00000645495B0YJ88
ENSG00000137710ENST00000645527A0A2R8Y7M3
ENSG00000137710ENST00000646663A0A2R8Y5S7
ENSG00000137710ENST00000647231P35241

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
Tight junctionKEGGko04530
Regulation of actin cytoskeletonKEGGko04810
Tight junctionKEGGhsa04530
Regulation of actin cytoskeletonKEGGhsa04810
Proteoglycans in cancerKEGGhsa05205
Proteoglycans in cancerKEGGko05205
MicroRNAs in cancerKEGGhsa05206
MicroRNAs in cancerKEGGko05206
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
L1CAM interactionsREACTOMER-HSA-373760
Recycling pathway of L1REACTOMER-HSA-437239

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
198900072009Phosphorylation of ezrin/radixin/moesin proteins by LRRK2 promotes the rearrangement of actin cytoskeleton in neuronal morphogenesis.148
172374452007Phosphorylated ERM is responsible for increased T cell polarization, adhesion, and migration in patients with systemic lupus erythematosus.70
191247452009Ezrin and moesin function together to promote T cell activation.58
192554422009LOK is a major ERM kinase in resting lymphocytes and regulates cytoskeletal rearrangement through ERM phosphorylation.58
150965112004The NHE1 Na+/H+ exchanger recruits ezrin/radixin/moesin proteins to regulate Akt-dependent cell survival.50
221798282012MicroRNA-409 suppresses tumour cell invasion and metastasis by directly targeting radixin in gastric cancers.44
226852022012Anoctamin 1 (Tmem16A) Ca2+-activated chloride channel stoichiometrically interacts with an ezrin-radixin-moesin network.43
172267842007Mutations of the RDX gene cause nonsyndromic hearing loss at the DFNB24 locus.38
175159522007Gene expression in temporal lobe epilepsy is consistent with increased release of glutamate by astrocytes.36
206793472010Differential effects of ceramide and sphingosine 1-phosphate on ERM phosphorylation: probing sphingolipid signaling at the outer plasma membrane.36

Citation

Dessen P

RDX (radixin)

Atlas Genet Cytogenet Oncol Haematol. 2009-03-01

Online version: http://atlasgeneticsoncology.org/gene/50787/rdx