REC8 (REC8 meiotic recombination protein)

2009-10-01  

Identity

HGNC
REC8
LOCATION
14q12
LOCUSID
9985
ALIAS
HR21spB,REC8L1,Rec8p
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9985
MIM: 608193
HGNC: 16879
Ensembl: ENSG00000100918

Variants:

dbSNP: 9985
ClinVar: 9985
TCGA: ENSG00000100918
COSMIC: REC8

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000100918ENST00000557806H0YMV7
ENSG00000100918ENST00000559797A0A075B715
ENSG00000100918ENST00000560501H0YM87
ENSG00000100918ENST00000611366O95072
ENSG00000100918ENST00000620473O95072

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Oocyte meiosisKEGGko04114
Oocyte meiosisKEGGhsa04114
Cell CycleREACTOMER-HSA-1640170
MeiosisREACTOMER-HSA-1500620
Meiotic synapsisREACTOMER-HSA-1221632

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
159357832005Absence of mouse REC8 cohesin promotes synapsis of sister chromatids in meiosis.114
203786152010Evaluation of 172 candidate polymorphisms for association with oligozoospermia or azoospermia in a large cohort of men of European descent.40
194638122009The role of meiotic cohesin REC8 in chromosome segregation in gamma irradiation-induced endopolyploid tumour cells.26
272120342017REC8 functions as a tumor suppressor and is epigenetically downregulated in gastric cancer, especially in EBV-positive subtype.13
264722822015REC8 is a novel tumor suppressor gene epigenetically robustly targeted by the PI3K pathway in thyroid cancer.7
293934742018REC8 inhibits EMT by downregulating EGR1 in gastric cancer cells.7
297249142018Studying meiotic cohesin in somatic cells reveals that Rec8-containing cohesin requires Stag3 to function and is regulated by Wapl and sororin.6
185700522008Analysis of the meiotic recombination gene REC8 for sequence variations in a population with severe male factor infertility.2
185700522008Analysis of the meiotic recombination gene REC8 for sequence variations in a population with severe male factor infertility.2

Citation

Dessen P

REC8 (REC8 meiotic recombination protein)

Atlas Genet Cytogenet Oncol Haematol. 2009-10-01

Online version: http://atlasgeneticsoncology.org/gene/51164/rec8