REEP5 (receptor accessory protein 5)

2014-11-01  

Identity

HGNC
REEP5
LOCATION
5q22.2
LOCUSID
7905
ALIAS
C5orf18,D5S346,DP1,POB16,TB2,YOP1,Yip2e
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 7905
MIM: 125265
HGNC: 30077
Ensembl: ENSG00000129625

Variants:

dbSNP: 7905
ClinVar: 7905
TCGA: ENSG00000129625
COSMIC: REEP5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000129625ENST00000261482E2QRG8
ENSG00000129625ENST00000379638Q00765
ENSG00000129625ENST00000504247B7Z332
ENSG00000129625ENST00000511865H0Y8J8
ENSG00000129625ENST00000513339B7Z510

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR downstream signalingREACTOMER-HSA-388396
Olfactory Signaling PathwayREACTOMER-HSA-381753

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA447321Depressive Disorder, MajorDiseaseClinicalAnnotationassociatedPD22795047
PA449015citalopramChemicalClinicalAnnotationassociatedPD22795047
PA449673fluoxetineChemicalClinicalAnnotationassociatedPD22795047
PA450801paroxetineChemicalClinicalAnnotationassociatedPD22795047
PA451333sertralineChemicalClinicalAnnotationassociatedPD22795047

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.11
227950472012Association of APC and REEP5 gene polymorphisms with major depression disorder and treatment response to antidepressants in a Han Chinese population.7
279666532016The accessory proteins REEP5 and REEP6 refine CXCR1-mediated cellular responses and lung cancer progression.5
320759612020REEP5 depletion causes sarco-endoplasmic reticulum vacuolization and cardiac functional defects.1

Citation

Dessen P

REEP5 (receptor accessory protein 5)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/72572/reep5