REG3A (regenerating family member 3 alpha)

2003-02-01  

Identity

HGNC
LOCATION
2p12
LOCUSID
ALIAS
HIP,HIP/PAP,INGAP,PAP,PAP-H,PAP1,PBCGF,REG-III,REG3
FUSION GENES

Other Information

Locus ID:

NCBI: 5068
MIM: 167805
HGNC: 8601
Ensembl: ENSG00000172016

Variants:

dbSNP: 5068
ClinVar: 5068
TCGA: ENSG00000172016
COSMIC: REG3A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000172016ENST00000305165Q06141
ENSG00000172016ENST00000305165Q53S56
ENSG00000172016ENST00000393878Q06141
ENSG00000172016ENST00000393878Q53S56
ENSG00000172016ENST00000409839Q06141
ENSG00000172016ENST00000409839Q53S56

Expression (GTEx)

0
500
1000
1500
2000

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Antimicrobial peptidesREACTOMER-HSA-6803157

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
169317622006Symbiotic bacteria direct expression of an intestinal bactericidal lectin.478
242567342014Antibacterial membrane attack by a pore-forming intestinal C-type lectin.79
227274892012The antimicrobial protein REG3A regulates keratinocyte proliferation and differentiation after skin injury.63
203828642010Molecular basis for peptidoglycan recognition by a bactericidal lectin.51
257518172015Myocardial healing requires Reg3β-dependent accumulation of macrophages in the ischemic heart.49
202019262010Human variation in alcohol response is influenced by variation in neuronal signaling genes.45
190956522009Regulation of C-type lectin antimicrobial activity by a flexible N-terminal prosegment.36
240964222013Differential induction of antimicrobial REGIII by the intestinal microbiota and Bifidobacterium breve NCC2950.34
264040022015IL17 Functions through the Novel REG3β-JAK2-STAT3 Inflammatory Pathway to Promote the Transition from Chronic Pancreatitis to Pancreatic Cancer.29
161166312005HIP/PAP accelerates liver regeneration and protects against acetaminophen injury in mice.25

Citation

Dessen P

REG3A (regenerating family member 3 alpha)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/487/reg3a