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REM1 (RRAD and GEM like GTPase 1)

Identity

Alias (NCBI)GD:REM
GES
HGNC (Hugo) REM1
HGNC Alias symbGES
HGNC Alias nameGTPase GES
HGNC Previous nameREM
HGNC Previous nameRAS (RAD and GEM)-like GTP-binding
LocusID (NCBI) 28954
Atlas_Id 72577
Location 20q11.21  [Link to chromosome band 20q11]
Location_base_pair Starts at 31475288 and ends at 31484905 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
TPX2 (20q11.21) / REM1 (20q11.21)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  TPX2/REM1 (20q11)

External links

Nomenclature
HGNC (Hugo)REM1   15922
Cards
Entrez_Gene (NCBI)REM1  28954  RRAD and GEM like GTPase 1
AliasesGD:REM; GES
GeneCards (Weizmann)REM1
Ensembl hg19 (Hinxton)ENSG00000088320 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000088320 [Gene_View]  ENSG00000088320 [Sequence]  chr20:31475288-31484905 [Contig_View]  REM1 [Vega]
ICGC DataPortalENSG00000088320
TCGA cBioPortalREM1
AceView (NCBI)REM1
Genatlas (Paris)REM1
WikiGenes28954
SOURCE (Princeton)REM1
Genetics Home Reference (NIH)REM1
Genomic and cartography
GoldenPath hg38 (UCSC)REM1  -     chr20:31475288-31484905 +  20q11.21   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)REM1  -     20q11.21   [Description]    (hg19-Feb_2009)
GoldenPathREM1 - 20q11.21 [CytoView hg19]  REM1 - 20q11.21 [CytoView hg38]
ImmunoBaseENSG00000088320
genome Data Viewer NCBIREM1 [Mapview hg19]  
OMIM610388   
Gene and transcription
Genbank (Entrez)AF084465 AF152863 AK313060 BC039813 BT020078
RefSeq transcript (Entrez)NM_014012
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)REM1
Alternative Splicing GalleryENSG00000088320
Gene ExpressionREM1 [ NCBI-GEO ]   REM1 [ EBI - ARRAY_EXPRESS ]   REM1 [ SEEK ]   REM1 [ MEM ]
Gene Expression Viewer (FireBrowse)REM1 [ Firebrowse - Broad ]
GenevisibleExpression of REM1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)28954
GTEX Portal (Tissue expression)REM1
Human Protein AtlasENSG00000088320-REM1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO75628   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO75628  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO75628
Splice isoforms : SwissVarO75628
PhosPhoSitePlusO75628
Domaine pattern : Prosite (Expaxy)RAS (PS51421)   
Domains : Interpro (EBI)P-loop_NTPase    RGK    Small_GTP-bd_dom    Small_GTPase    Small_GTPase_Ras-type   
Domain families : Pfam (Sanger)Ras (PF00071)   
Domain families : Pfam (NCBI)pfam00071   
Conserved Domain (NCBI)REM1
DMDM Disease mutations28954
Blocks (Seattle)REM1
PDB (RSDB)2NZJ   
PDB Europe2NZJ   
PDB (PDBSum)2NZJ   
PDB (IMB)2NZJ   
Structural Biology KnowledgeBase2NZJ   
SCOP (Structural Classification of Proteins)2NZJ   
CATH (Classification of proteins structures)2NZJ   
SuperfamilyO75628
Human Protein Atlas [tissue]ENSG00000088320-REM1 [tissue]
Peptide AtlasO75628
HPRD15237
IPIIPI00289912   
Protein Interaction databases
DIP (DOE-UCLA)O75628
IntAct (EBI)O75628
FunCoupENSG00000088320
BioGRIDREM1
STRING (EMBL)REM1
ZODIACREM1
Ontologies - Pathways
QuickGOO75628
Ontology : AmiGOGTPase activity  calcium channel regulator activity  calmodulin binding  GTP binding  plasma membrane  signal transduction  negative regulation of high voltage-gated calcium channel activity  
Ontology : EGO-EBIGTPase activity  calcium channel regulator activity  calmodulin binding  GTP binding  plasma membrane  signal transduction  negative regulation of high voltage-gated calcium channel activity  
NDEx NetworkREM1
Atlas of Cancer Signalling NetworkREM1
Wikipedia pathwaysREM1
Orthology - Evolution
OrthoDB28954
GeneTree (enSembl)ENSG00000088320
Phylogenetic Trees/Animal Genes : TreeFamREM1
HOGENOMO75628
Homologs : HomoloGeneREM1
Homology/Alignments : Family Browser (UCSC)REM1
Gene fusions - Rearrangements
Fusion : QuiverREM1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerREM1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)REM1
dbVarREM1
ClinVarREM1
1000_GenomesREM1 
Exome Variant ServerREM1
GNOMAD BrowserENSG00000088320
Varsome BrowserREM1
Genetic variants : HAPMAP28954
Genomic Variants (DGV)REM1 [DGVbeta]
DECIPHERREM1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisREM1 
Mutations
ICGC Data PortalREM1 
TCGA Data PortalREM1 
Broad Tumor PortalREM1
OASIS PortalREM1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICREM1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DREM1
Mutations and Diseases : HGMDREM1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch REM1
DgiDB (Drug Gene Interaction Database)REM1
DoCM (Curated mutations)REM1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)REM1 (select a term)
intoGenREM1
Cancer3DREM1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610388   
Orphanet
DisGeNETREM1
MedgenREM1
Genetic Testing Registry REM1
NextProtO75628 [Medical]
TSGene28954
GENETestsREM1
Target ValidationREM1
Huge Navigator REM1 [HugePedia]
snp3D : Map Gene to Disease28954
BioCentury BCIQREM1
ClinGenREM1
Clinical trials, drugs, therapy
Protein Interactions : CTD28954
Pharm GKB GenePA34324
Clinical trialREM1
Miscellaneous
canSAR (ICR)REM1 (select the gene name)
HarmonizomeREM1
DataMed IndexREM1
Probes
Litterature
PubMed12 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineREM1
EVEXREM1
GoPubMedREM1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Jul 16 16:25:05 CEST 2020
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