REV3L (REV3 like, DNA directed polymerase zeta catalytic subunit)

2003-02-01  

Identity

HGNC
LOCATION
6q21
LOCUSID
ALIAS
POLZ,REV3
FUSION GENES

Other Information

Locus ID:

NCBI: 5980
MIM: 602776
HGNC: 9968
Ensembl: ENSG00000009413

Variants:

dbSNP: 5980
ClinVar: 5980
TCGA: ENSG00000009413
COSMIC: REV3L

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000009413ENST00000358835O60673
ENSG00000009413ENST00000368802O60673
ENSG00000009413ENST00000413831H0Y5T4
ENSG00000009413ENST00000422377F2Z3A1
ENSG00000009413ENST00000434009F2Z3A1
ENSG00000009413ENST00000435970O60673
ENSG00000009413ENST00000619481A0A087WZU4

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50

Pathways

PathwaySourceExternal ID
Metabolic pathwaysKEGGhsa01100
Fanconi anemia pathwayKEGGko03460
Fanconi anemia pathwayKEGGhsa03460
DNA polymerase zeta complexKEGGhsa_M00293
DNA polymerase zeta complexKEGGM00293
DNA RepairREACTOMER-HSA-73894
DNA Damage BypassREACTOMER-HSA-73893
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templateREACTOMER-HSA-110313
Translesion synthesis by REV1REACTOMER-HSA-110312
Translesion synthesis by POLKREACTOMER-HSA-5655862
Translesion synthesis by POLIREACTOMER-HSA-5656121
Platinum drug resistanceKEGGko01524
Platinum drug resistanceKEGGhsa01524

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA128406956fluorouracilChemicalClinicalAnnotationassociatedPD
PA445058Neoplasm MetastasisDiseaseClinicalAnnotationassociatedPD
PA445601OsteosarcomaDiseaseClinicalAnnotationassociatedPD
PA448771capecitabineChemicalClinicalAnnotationassociatedPD
PA449014cisplatinChemicalClinicalAnnotationassociatedPD

References

Pubmed IDYearTitleCitations
244499062014Human Pol ζ purified with accessory subunits is active in translesion DNA synthesis and complements Pol η in cisplatin bypass.73
200287362010Differential roles for DNA polymerases eta, zeta, and REV1 in lesion bypass of intrastrand versus interstrand DNA cross-links.70
201641942010Crystal structure of human REV7 in complex with a human REV3 fragment and structural implication of the interaction between DNA polymerase zeta and REV1.58
201641942010Crystal structure of human REV7 in complex with a human REV3 fragment and structural implication of the interaction between DNA polymerase zeta and REV1.58
195646182009DNA polymerase zeta cooperates with polymerases kappa and iota in translesion DNA synthesis across pyrimidine photodimers in cells from XPV patients.54
219261602012REV1 and polymerase ζ facilitate homologous recombination repair.52
228592962012Structural basis of recruitment of DNA polymerase ζ by interaction between REV1 and REV7 proteins.43
124594442002hREV3 is essential for error-prone translesion synthesis past UV or benzo[a]pyrene diol epoxide-induced DNA lesions in human fibroblasts.39
220286212011Inhibition of REV3 expression induces persistent DNA damage and growth arrest in cancer cells.35
233037712013Rev3, the catalytic subunit of Polζ, is required for maintaining fragile site stability in human cells.35

Citation

Dessen P

REV3L (REV3 like, DNA directed polymerase zeta catalytic subunit)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42086/rev3l