REXO2 (RNA exonuclease 2)

2004-04-01  

Identity

HGNC
REXO2
LOCATION
11q23.2
LOCUSID
25996
ALIAS
CGI-114,REX2,RFN,SFN
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 25996
MIM: 607149
HGNC: 17851
Ensembl: ENSG00000076043

Variants:

dbSNP: 25996
ClinVar: 25996
TCGA: ENSG00000076043
COSMIC: REXO2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000076043ENST00000265881Q9Y3B8
ENSG00000076043ENST00000538198H0YG37
ENSG00000076043ENST00000539119H0YGR4
ENSG00000076043ENST00000539275Q9BTR4
ENSG00000076043ENST00000539754F5GYG5
ENSG00000076043ENST00000541703F5H784
ENSG00000076043ENST00000543131F5H7P1
ENSG00000076043ENST00000544196F5H6P8
ENSG00000076043ENST00000544827H0YG54
ENSG00000076043ENST00000546316H0YF66
ENSG00000076043ENST00000611665Q9Y3B8

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Ribosome biogenesis in eukaryotesKEGGko03008
Ribosome biogenesis in eukaryotesKEGGhsa03008

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
237413652013REXO2 is an oligoribonuclease active in human mitochondria.25
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.17
180235902008Hydrolysis of the 5'-p-nitrophenyl ester of TMP by oligoribonucleases (ORN) from Escherichia coli, Mycobacterium smegmatis, and human.6
309267542019Structural insights into nanoRNA degradation by human Rexo2.5
241027002013The epithelium specific cell cycle regulator 14-3-3sigma is required for preventing entry into mitosis following ultraviolet B.4
26346170201614-3-3σ confers cisplatin resistance in esophageal squamous cell carcinoma cells via regulating DNA repair molecules.4
153629352004Involvement of human small fragment nuclease in the resistance of human cells to UV-C-induced cell death.3
26147002201514-3-3 Binding and Sumoylation Concur to the Down-Modulation of β-catenin Antagonist chibby 1 in Chronic Myeloid Leukemia.3
315880222019Dinucleotide Degradation by REXO2 Maintains Promoter Specificity in Mammalian Mitochondria.1

Citation

Dessen P

REXO2 (RNA exonuclease 2)

Atlas Genet Cytogenet Oncol Haematol. 2004-04-01

Online version: http://atlasgeneticsoncology.org/gene/40321/rexo2