RFTN1 (raftlin, lipid raft linker 1)

2013-07-01  

Identity

HGNC
RFTN1
LOCATION
3p24.3
LOCUSID
23180
ALIAS
MIG2,PIB10,PIG9,RAFTLIN
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 23180
MIM: 618210
HGNC: 30278
Ensembl: ENSG00000131378

Variants:

dbSNP: 23180
ClinVar: 23180
TCGA: ENSG00000131378
COSMIC: RFTN1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000131378ENST00000334133Q14699
ENSG00000131378ENST00000431547C9JWQ9
ENSG00000131378ENST00000432519G3XAJ6
ENSG00000131378ENST00000441460C9JRN3
ENSG00000131378ENST00000449415C9JRN3
ENSG00000131378ENST00000451036C9JHG2
ENSG00000131378ENST00000453536F8WAR1
ENSG00000131378ENST00000607320U3KPZ2

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
198345352009Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging.27
128052162003The B cell-specific major raft protein, Raftlin, is necessary for the integrity of lipid raft and BCR signal transduction.22
212665792011Raftlin is involved in the nucleocapture complex to induce poly(I:C)-mediated TLR3 activation.22
222225112012Interactive effects of ATOH7 and RFTN1 in association with adult-onset primary open-angle glaucoma.13
270221952016Raftlin Controls Lipopolysaccharide-Induced TLR4 Internalization and TICAM-1 Signaling in a Cell Type-Specific Manner.6
236457462013Mitogen-inducible Gene-2 (MIG2) and migfilin expression is reduced in samples of human breast cancer.4

Citation

Dessen P

RFTN1 (raftlin, lipid raft linker 1)

Atlas Genet Cytogenet Oncol Haematol. 2013-07-01

Online version: http://atlasgeneticsoncology.org/gene/53450/rftn1