RGMA (repulsive guidance molecule BMP co-receptor a)

2009-08-01  

Identity

HGNC
RGMA
LOCATION
15q26.1
LOCUSID
56963
ALIAS
RGM
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 56963
MIM: 607362
HGNC: 30308
Ensembl: ENSG00000182175

Variants:

dbSNP: 56963
ClinVar: 56963
TCGA: ENSG00000182175
COSMIC: RGMA

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000182175ENST00000329082Q96B86
ENSG00000182175ENST00000425933Q96B86
ENSG00000182175ENST00000542321Q96B86
ENSG00000182175ENST00000543599Q96B86
ENSG00000182175ENST00000554387G3V3Z3
ENSG00000182175ENST00000555598G3V4C2
ENSG00000182175ENST00000556658F5H7G2
ENSG00000182175ENST00000556950A0A0G2JL92
ENSG00000182175ENST00000557301A0A0A0MTQ4
ENSG00000182175ENST00000557420G3V545

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
Netrin-1 signalingREACTOMER-HSA-373752

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
174729602007Repulsive guidance molecule RGMa alters utilization of bone morphogenetic protein (BMP) type II receptors by BMP2 and BMP4.44
192736162009Unc5B associates with LARG to mediate the action of repulsive guidance molecule.43
214672232011Repulsive guidance molecule-A (RGM-A) inhibits leukocyte migration and mitigates inflammation.26
162169392005Central nervous system injury-induced repulsive guidance molecule expression in the adult human brain.22
200721402010RGMA and IL21R show association with experimental inflammation and multiple sclerosis.22
193030192009Frequent inactivation of axon guidance molecule RGMA in human colon cancer through genetic and epigenetic mechanisms.19
183671542008Linkage disequilibrium mapping of a chromosome 15q25-26 major depression linkage region and sequencing of NTRK3.13
294786982018Genome-wide Association Study Identifies a Regulatory Variant of RGMA Associated With Opioid Dependence in European Americans.11
220764992012Repulsive guidance molecules, novel bone morphogenetic protein co-receptors, are key regulators of the growth and aggressiveness of prostate cancer cells.9
216172292011Potential prognostic value of repulsive guidance molecules in breast cancer.7

Citation

Dessen P

RGMA (repulsive guidance molecule BMP co-receptor a)

Atlas Genet Cytogenet Oncol Haematol. 2009-08-01

Online version: http://atlasgeneticsoncology.org/gene/51052/rgma