RGS12 (regulator of G protein signaling 12)

2003-12-01  

Identity

HGNC
RGS12
LOCATION
4p16.3
LOCUSID
6002
ALIAS
-
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 6002
MIM: 602512
HGNC: 9994
Ensembl: ENSG00000159788

Variants:

dbSNP: 6002
ClinVar: 6002
TCGA: ENSG00000159788
COSMIC: RGS12

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000159788ENST00000336727O14924
ENSG00000159788ENST00000338806O14924
ENSG00000159788ENST00000344733O14924
ENSG00000159788ENST00000382788O14924
ENSG00000159788ENST00000514268E9PBG5
ENSG00000159788ENST00000643191A0A2R8YCJ1

Expression (GTEx)

0
5
10
15
20
25
30
35
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594

References

Pubmed IDYearTitleCitations
91689311997Molecular cloning and expression analysis of rat Rgs12 and Rgs14.33
170427162007RGS12 is essential for RANKL-evoked signaling for terminal differentiation of osteoclasts in vitro.27
201983152010Association of genetic variants with hemorrhagic stroke in Japanese individuals.11
286110452017RGS12 Is a Novel Tumor-Suppressor Gene in African American Prostate Cancer That Represses AKT and MNX1 Expression.9
206278712010Genetic variations in regulator of G-protein signaling genes as susceptibility loci for second primary tumor/recurrence in head and neck squamous cell carcinoma.5
198512962010Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals.3
269878132016Regulator of G-protein signalling and GoLoco proteins suppress TRPC4 channel function via acting at Gαi/o.3

Citation

Dessen P

RGS12 (regulator of G protein signaling 12)

Atlas Genet Cytogenet Oncol Haematol. 2003-12-01

Online version: http://atlasgeneticsoncology.org/gene/42100/rgs12