RGS13 (regulator of G protein signaling 13)

2007-02-01  

Identity

HGNC
RGS13
LOCATION
1q31.2
LOCUSID
6003
ALIAS
-

Other Information

Locus ID:

NCBI: 6003
MIM: 607190
HGNC: 9995
Ensembl: ENSG00000127074

Variants:

dbSNP: 6003
ClinVar: 6003
TCGA: ENSG00000127074
COSMIC: RGS13

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000127074ENST00000391995O14921
ENSG00000127074ENST00000391995A0A024R989
ENSG00000127074ENST00000543215O14921
ENSG00000127074ENST00000543215A0A024R989

Expression (GTEx)

0
1
2
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
204680642010Association study of 182 candidate genes in anorexia nervosa.30
165653222006RGS1 and RGS13 mRNA silencing in a human B lymphoma line enhances responsiveness to chemoattractants and impairs desensitization.24
129707902003High level of cannabinoid receptor 1, absence of regulator of G protein signalling 13 and differential expression of Cyclin D1 in mantle cell lymphoma.23
118750762002Functional characterization of the G protein regulator RGS13.22
190179782008RGS13 controls g protein-coupled receptor-evoked responses of human mast cells.21
209746832010Phosphorylation of RGS13 by the cyclic AMP-dependent protein kinase inhibits RGS13 degradation.9
206278712010Genetic variations in regulator of G-protein signaling genes as susceptibility loci for second primary tumor/recurrence in head and neck squamous cell carcinoma.5
303080122018MicroRNA and mRNA expression associated with ectopic germinal centers in thymus of myasthenia gravis.5
215317262011p53 negatively regulates RGS13 protein expression in immune cells.4

Citation

Dessen P

RGS13 (regulator of G protein signaling 13)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43608/rgs13