Atlas of Genetics and Cytogenetics in Oncology and Haematology

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RGS20 (regulator of G protein signaling 20)

Identity

Alias_namesregulator of G-protein signalling 20
regulator of G-protein signaling 20
Alias_symbol (synonym)RGSZ1
ZGAP1
Other aliasg(z)GAP
gz-GAP
HGNC (Hugo) RGS20
LocusID (NCBI) 8601
Atlas_Id 47000
Location 8q11.23  [Link to chromosome band 8q11]
Location_base_pair Starts at 53851808 and ends at 53959304 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CDK7 (5q13.2) / RGS20 (8q11.23)RGS20 (8q11.23) / RGS20 (8q11.23)CDK7 5q13.2 / RGS20 8q11.23

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(5;8)(q13;q11) CDK7/RGS20

External links

Nomenclature
HGNC (Hugo)RGS20   14600
Cards
Entrez_Gene (NCBI)RGS20  8601  regulator of G protein signaling 20
AliasesRGSZ1; ZGAP1; g(z)GAP; gz-GAP
GeneCards (Weizmann)RGS20
Ensembl hg19 (Hinxton)ENSG00000147509 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000147509 [Gene_View]  ENSG00000147509 [Sequence]  chr8:53851808-53959304 [Contig_View]  RGS20 [Vega]
ICGC DataPortalENSG00000147509
TCGA cBioPortalRGS20
AceView (NCBI)RGS20
Genatlas (Paris)RGS20
WikiGenes8601
SOURCE (Princeton)RGS20
Genetics Home Reference (NIH)RGS20
Genomic and cartography
GoldenPath hg38 (UCSC)RGS20  -     chr8:53851808-53959304 +  8q11.23   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RGS20  -     8q11.23   [Description]    (hg19-Feb_2009)
GoldenPathRGS20 - 8q11.23 [CytoView hg19]  RGS20 - 8q11.23 [CytoView hg38]
ImmunoBaseENSG00000147509
Mapping of homologs : NCBIRGS20 [Mapview hg19]  RGS20 [Mapview hg38]
OMIM607193   
Gene and transcription
Genbank (Entrez)AF060877 AF074979 AF366054 AF366055 AF366056
RefSeq transcript (Entrez)NM_001286673 NM_001286674 NM_001286675 NM_003702 NM_170587
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)RGS20
Cluster EST : UnigeneHs.368733 [ NCBI ]
CGAP (NCI)Hs.368733
Alternative Splicing GalleryENSG00000147509
Gene ExpressionRGS20 [ NCBI-GEO ]   RGS20 [ EBI - ARRAY_EXPRESS ]   RGS20 [ SEEK ]   RGS20 [ MEM ]
Gene Expression Viewer (FireBrowse)RGS20 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8601
GTEX Portal (Tissue expression)RGS20
Human Protein AtlasENSG00000147509-RGS20 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO76081   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO76081  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO76081
Splice isoforms : SwissVarO76081
PhosPhoSitePlusO76081
Domaine pattern : Prosite (Expaxy)RGS (PS50132)   
Domains : Interpro (EBI)RGS    RGS_sf   
Domain families : Pfam (Sanger)RGS (PF00615)   
Domain families : Pfam (NCBI)pfam00615   
Domain families : Smart (EMBL)RGS (SM00315)  
Conserved Domain (NCBI)RGS20
DMDM Disease mutations8601
Blocks (Seattle)RGS20
SuperfamilyO76081
Human Protein Atlas [tissue]ENSG00000147509-RGS20 [tissue]
Peptide AtlasO76081
HPRD06225
IPIIPI00008802   IPI00220880   IPI00220881   IPI00220882   IPI00220883   IPI00220884   IPI00983611   IPI00984221   IPI00794706   
Protein Interaction databases
DIP (DOE-UCLA)O76081
IntAct (EBI)O76081
FunCoupENSG00000147509
BioGRIDRGS20
STRING (EMBL)RGS20
ZODIACRGS20
Ontologies - Pathways
QuickGOO76081
Ontology : AmiGOGTPase activity  GTPase activator activity  protein binding  nucleus  cytoplasm  trans-Golgi network  plasma membrane  G protein-coupled receptor signaling pathway  regulation of G protein-coupled receptor signaling pathway  negative regulation of signal transduction  positive regulation of GTPase activity  
Ontology : EGO-EBIGTPase activity  GTPase activator activity  protein binding  nucleus  cytoplasm  trans-Golgi network  plasma membrane  G protein-coupled receptor signaling pathway  regulation of G protein-coupled receptor signaling pathway  negative regulation of signal transduction  positive regulation of GTPase activity  
NDEx NetworkRGS20
Atlas of Cancer Signalling NetworkRGS20
Wikipedia pathwaysRGS20
Orthology - Evolution
OrthoDB8601
GeneTree (enSembl)ENSG00000147509
Phylogenetic Trees/Animal Genes : TreeFamRGS20
HOGENOMO76081
Homologs : HomoloGeneRGS20
Homology/Alignments : Family Browser (UCSC)RGS20
Gene fusions - Rearrangements
Fusion : MitelmanCDK7/RGS20 [5q13.2/8q11.23]  [t(5;8)(q13;q11)]  
Fusion PortalCDK7 5q13.2 RGS20 8q11.23 BRCA
Fusion : QuiverRGS20
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRGS20 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RGS20
dbVarRGS20
ClinVarRGS20
1000_GenomesRGS20 
Exome Variant ServerRGS20
ExAC (Exome Aggregation Consortium)ENSG00000147509
GNOMAD BrowserENSG00000147509
Varsome BrowserRGS20
Genetic variants : HAPMAP8601
Genomic Variants (DGV)RGS20 [DGVbeta]
DECIPHERRGS20 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRGS20 
Mutations
ICGC Data PortalRGS20 
TCGA Data PortalRGS20 
Broad Tumor PortalRGS20
OASIS PortalRGS20 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRGS20  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DRGS20
Mutations and Diseases : HGMDRGS20
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RGS20
DgiDB (Drug Gene Interaction Database)RGS20
DoCM (Curated mutations)RGS20 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RGS20 (select a term)
intoGenRGS20
Cancer3DRGS20(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607193   
Orphanet
DisGeNETRGS20
MedgenRGS20
Genetic Testing Registry RGS20
NextProtO76081 [Medical]
TSGene8601
GENETestsRGS20
Target ValidationRGS20
Huge Navigator RGS20 [HugePedia]
snp3D : Map Gene to Disease8601
BioCentury BCIQRGS20
ClinGenRGS20
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8601
Chemical/Pharm GKB GenePA34373
Clinical trialRGS20
Miscellaneous
canSAR (ICR)RGS20 (select the gene name)
DataMed IndexRGS20
Probes
Litterature
PubMed32 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRGS20
EVEXRGS20
GoPubMedRGS20
iHOPRGS20
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Nov 13 18:04:50 CET 2019
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